Lipid homeostasis mediated by cholesterol synthesis supports B cell responses to vaccination

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Nature Immunology | 2023年 / 24卷
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Sterol regulatory element-binding protein (SREBP) signaling regulates cellular lipid homeostasis. We discovered that SREBP signaling in B cells is crucial for antibody responses and the generation of germinal centers and B cell memory compartments in response to vaccination. These results provide mechanistic insights that couple sterol metabolism to the quality and longevity of humoral immunity.
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页码：216 / 217
页数：1
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