Activation of a promyelocytic leukemia–tumor protein 53 axis underlies acute promyelocytic leukemia cure

被引：0

作者：

Julien Ablain

Kim Rice

Hassane Soilihi

Aurélien de Reynies

Saverio Minucci

Hugues de Thé

机构：

[1] Université Paris Diderot,Department of Experimental Oncology

[2] Sorbonne Paris Cité,Department of Biosciences

[3] Hôpital St. Louis,undefined

[4] INSERM UMR 944,undefined

[5] Equipe Labellisée par la Ligue Nationale contre le Cancer,undefined

[6] Institut Universitaire d'Hématologie,undefined

[7] Hôpital St. Louis,undefined

[8] CNRS UMR 7212,undefined

[9] Hôpital St. Louis,undefined

[10] Programme Cartes d'Identité des Tumeurs,undefined

[11] Ligue Nationale contre le Cancer,undefined

[12] European Institute of Oncology,undefined

[13] University of Milan,undefined

[14] Assistance Publique Hôpitaux de Paris,undefined

[15] Service de Biochimie,undefined

[16] Hôpital St. Louis,undefined

[17] Present address: Stem Cell Program and Division of Hematology/Oncology,undefined

[18] Children's Hospital and Dana-Farber Cancer Institute,undefined

[19] Boston,undefined

[20] Massachusetts,undefined

[21] USA.,undefined

来源：

Nature Medicine | 2014年 / 20卷

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摘要：

Retinoic acid and arsenic therapies have shown considerable efficacy in patients with acute promyelocytic leukemia, but their exact mechanism of action remains unclear. Here, Hugues de Thé and colleagues uncover a therapeutic effect mediated by nuclear body reformation and p53 activation that involves the induction of a senescence transcriptional program. These data suggest that redifferentiation and apoptosis induction may not be sufficient for the effect of these agents in patients and uncover alternative therapeutic routes that could be applied to other tumor and treatment types.

引用

页码：167 / 174

页数：7

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