Long non-coding RNAs regulate drug resistance in cancer

被引:0
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作者
Kaisheng Liu
Lin Gao
Xiaoshi Ma
Juan-Juan Huang
Juan Chen
Leli Zeng
Charles R. Ashby
Chang Zou
Zhe-Sheng Chen
机构
[1] The First Affiliated Hospital of Southern University of Science and Technology,Department of Physics
[2] The Second Clinical Medical College of Jinan University,College of Pharmacy and Health Sciences
[3] Shenzhen People’s Hospital,Tomas Lindahl Nobel Laureate Laboratory, Research Centre, The Seventh Affiliated Hospital
[4] Technical University of Munich,undefined
[5] St. John’s University,undefined
[6] Queens,undefined
[7] Sun Yat-sen University,undefined
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关键词
Cancer; Drug resistance; Long non-coding RNAs;
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摘要
Chemoresistance, whether intrinsic or acquired, is a major obstacle in the treatment of cancer. The resistance of cancer cells to chemotherapeutic drugs can result from various mechanisms. Over the last decade, it has been reported that 1ong noncoding RNAs (lncRNAs) can mediate carcinogenesis and drug resistance/sensitivity in cancer cells. This article reviews, in detail, recent studies regarding the roles of lncRNAs in mediating drug resistance.
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