Cytoskeletal keratin glycosylation protects epithelial tissue from injury

被引：0
|
作者：
Nam-On Ku
Diana M. Toivola
Pavel Strnad
M. Bishr Omary
机构：
[1] University of Michigan Medical School,Department of Molecular & Integrative Physiology
[2] Graduate School,Department of Biomedical Sciences
[3] Yonsei University,Department of Biosciences
[4] Åbo Akademi University,Department of Internal Medicine I
[5] University Medical Center Ulm,undefined
来源：
Nature Cell Biology | 2010年 / 12卷
关键词：
D O I：
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学科分类号：
摘要：
Keratin 8 and 18 protect hepatocytes from apoptosis. Inhibiting keratin 18 glycosylation is shown to sensitize cells to liver and pancreatic injury and apoptosis, through a pathway involving Akt and PKCθ.
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页码：876 / 885
页数：9
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