Rearing by foster Wistar mother with high level of maternal care counteracts the development of genetic absence epilepsy and comorbid depression in WAG/Rij rats

被引：10
|
作者：
Sarkisova K.Y. [1 ]
Gabova A.V. [1 ]
Kulikov M.A. [1 ]
Fedosova E.A. [1 ]
Shatskova A.B. [1 ]
Morosov A.A. [2 ]
机构：
[1] Institute of Higher Nervous Activity and Neurophysiology RAS, Moscow
[2] Institute of Radio Engineering and Radioelectronics RAS, Moscow
来源：
Doklady Biological Sciences | 2017年 / 473卷 / 1期
基金：
俄罗斯基础研究基金会;
关键词：
D O I：
10.1134/S0012496617020077
中图分类号：
学科分类号：
摘要：
It has been shown for the first time that rearing by a foster Wistar mother with high level of maternal care (MC) counteracts the expression of genetic absence epilepsy (AE) and comorbid depression – reduces the number, duration and index of spike-wave discharges (SWDs) and immobility time in the forced swimming test, as well as exerts substantial effects on morphology and time-frequency dynamics of SWDs in WAG/Rij rats. It is supposed that increases in MC early in development might be used to counteract epileptogenesis and comorbid depression in people genetically predisposed to AE. © 2017, Pleiades Publishing, Ltd.
引用
收藏
页码：39 / 42
页数：3
相关论文
共 22 条
  • [1] IMPROVED MATERNAL CARE OF FOSTER WISTAR MOTHER EARLY IN DEVELOPMENT REDUCES SEIZURE ACTIVITY, ANXIETY AND DEPRESSION-LIKE COMORBIDITY IN ADULT WAG/RIJ RATS WITH GENETIC PREDISPOSITION TO ABSENCE EPILEPSY
    Sarkisova, K.
    Tanaeva, K.
    Midzyanovskaya, I.
    Suleymanova, E.
    EPILEPSIA, 2015, 56 : 205 - 205
  • [2] Effects of Postnatal Caffeine Exposure on Absence Epilepsy and Comorbid Depression: Results of a Study in WAG/Rij Rats
    Ilbay, Gul
    Dogan, Zeynep Ikbal
    Balikci, Aymen
    Erdogan, Seyda
    Kahilogullari, Akfer Karaoglan
    BRAIN SCIENCES, 2022, 12 (03)
  • [3] Tactile stimulation of young WAG/Rij rats prevents development of depression but not absence epilepsy
    Balikci, Aymen
    Eryilmaz, Ugur
    Guler, Vildan Keles
    Ilbay, Gul
    FRONTIERS IN BEHAVIORAL NEUROSCIENCE, 2024, 18
  • [4] Ethosuximide Improves Cognitive Flexibility during Reversal Learning in WAG/Rij Rats with Absence Epilepsy and Comorbid Depression
    Fedosova, E. A.
    Shatskova, A. B.
    Sarkisova, K. Yu
    JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY, 2022, 58 (01) : 98 - 116
  • [5] Ethosuximide Improves Cognitive Flexibility during Reversal Learning in WAG/Rij Rats with Absence Epilepsy and Comorbid Depression
    E. A. Fedosova
    A. B. Shatskova
    K. Yu. Sarkisova
    Journal of Evolutionary Biochemistry and Physiology, 2022, 58 : 98 - 116
  • [6] Gender-Dependent Effect of Maternal Methyl-Enriched Diet on the Expression of Genetic Absence Epilepsy and Comorbid Depression in Adult Offspring of WAG/Rij Rats
    Sarkisova K.Y.
    Gabova A.V.
    Fedosova E.A.
    Shatskova A.B.
    Doklady Biological Sciences, 2020, 494 (1) : 244 - 247
  • [7] Dopamine-dependent nature of depression-like behavior in WAG/Rij rats with genetic absence epilepsy
    Sarkisova K.Yu.
    Kulikov M.A.
    Midzyanovskaya I.S.
    Folomkina A.A.
    Neuroscience and Behavioral Physiology, 2008, 38 (2) : 119 - 128
  • [8] Reduction of Hippocampal High-Frequency Activity in Wag/Rij Rats with a Genetic Predisposition to Absence Epilepsy
    Sitnikova, Evgenia
    Perevozniuk, Dmitrii
    Rutskova, Elizaveta
    Uzakov, Shukhrat
    Korshunov, Viktor A. A.
    DIAGNOSTICS, 2022, 12 (11)
  • [9] Cytokine gene polymorphism in Wistar Albino Glaxo rats from Rijs']jswijk (WAG/Rij) rats which are genetic models of absence epilepsy
    Gurol, Gonul
    Tekin, Nilgun
    Yildizhan, Hatice
    Sari, Sibel
    Arkan, Sertan
    Ates, Nurbay
    Demiralp, Duygu Ozel
    JOURNAL OF BIOTECHNOLOGY, 2014, 185 : S89 - S89
  • [10] Comparison of cortical epileptic afterdischarges in immature genetic absence epilepsy WAG/Rij rats with those in two other strains (ACI and Wistar)
    Mares, Pavel
    Tolmacheva, Elena
    EPILEPSIA, 2007, 48 : 164 - 167
123