Interplay of the transcription factor MRTF-A and matrix stiffness controls mammary acinar structure and protrusion formation

被引：0
|
作者：
Marie-Luise Melcher
Ines Block
Karolin Kropf
Anurag Kumar Singh
Guido Posern
机构：
[1] Martin Luther University Halle-Wittenberg,Institute for Physiological Chemistry, Medical Faculty
来源：
Cell Communication and Signaling | / 20卷
关键词：
Mrtf; Mammary acini; Mechanotransduction; Stiffness; Protrusion formation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Formation of mammary acini depends on crosstalk between matrix stiffness and MRTF-A Increased matrix stiffness elevates MRTF-A activity and protrusion formationProtrusion formation of MCF10A-derived and primary murine acini is MRTF-dependent Genetic MRTF-A activation in primary organoids is sufficient for luminal filling
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