Selective mutation in ATP-binding site reduces affinity of drug to the kinase: a possible mechanism of chemo-resistance

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作者：
Nuzhat N. Kabir
Julhash U. Kazi
机构：
[1] KN Biomedical Research Institute,Laboratory of Computational Biochemistry
[2] Lund University,Experimental Clinical Chemistry, Department of Laboratory Medicine
来源：
Medical Oncology | 2013年 / 30卷
关键词：
Kinase Domain; Important Residue; Selective Mutation; Individual Residue; Eukaryotic Protein Kinase;
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