Coltricia globispora sp. nov. is described as new based on specimens collected in the Parque Natural Municipal de Porto Velho, in the state of Rondônia, Brazilian Amazonia. It is characterized by small pores (7–8 per mm), monomitic hyphal system, and globose, smooth and guttulate basidiospores (5.5–6.6 (−7) μm). Phellinus griseoporus has been found for the first time in Brazil, and Cyclomyces iodinus, P. merrillii, P. membranaceus and P. umbrinellus in the Brazilian Amazonia. Coltricia cinnamomea, P. calcitratus and Phylloporia chrysites are new occurrences to the state Rondônia, while C. hamata and Phylloporia spathulata to the state of Pará. The knowledge about Hymenochaetaceae in the Brazilian Amazonia is briefly discussed, and a key to the neotropical species of Coltricia is provided.