Cyclic Amidoalkylation of Hydrophosphorylic Compounds. Synthesis of Proline Analogs

被引：0
|
作者：
A. V. Vinyukov
M. E. Dmitriev
A. N. Yarkevich
V. V. Ragulin
机构：
[1] Russian Academy of Sciences,Institute of Physiologically Active Substances
来源：
Russian Journal of General Chemistry | 2017年 / 87卷
关键词：
phosphorylic analogs of proline; cyclic amidoalkylation; 4-aminobutyraldehyde;
D O I：
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中图分类号：
学科分类号：
摘要：
A method for the synthesis of N-Cbz-protected phosphorylic analogs of proline by cyclic amidoalkylation of various hydrophosphorylic compounds was developed. Combination of amide and carbonyl fragments in the 4-N-Cbz-aminobutyraldehyde molecule allows to realize the three-center two-component amide version of the Kabachnik–Fields reaction.
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页码：2898 / 2901
页数：3
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