Air pollution increased risk of reproductive system diseases: a 5-year outcome analysis of different pollutants in different seasons, ages, and genders

Air pollution remains a serious environmental problem worldwide, and the effects of air pollutants with reproductive system diseases have already attracted extensive attention. The present study investigated the risk of air pollutants on reproductive system diseases, based on daily medical visits (DMV) of the past 5 years in central China. Data of DMV outpatients with reproductive system diseases were obtained from a general hospital in Zhengzhou, October 28, 2013 to May 31, 2018, as well as atmospheric pollutants data. Correlation of air pollutants and DMV was analyzed with distributed lag nonlinear model (DLNM), including total cases of reproductive system diseases, and in different seasons (spring, summer, autumn, and winter), genders (male and female), and age groups (<26, 26–35, and >35 years old). A total of 374,558 visits were included. NO2 was most closely relevant to incidence risk of total cases analysis with each increased interquartile ranges (IQRs) in the 6 pollutants, with 30-day lag. Relationship to pollutants was more sensitive in fall, >35 years old, and male groups than in other seasons, ages, and females, and NO2 had the highest risk on reproductive diseases. Air pollution increased risk of reproductive system diseases, and different pollutants played different roles in different seasons, ages, and genders. The results of this study will provide evidence for effective air quality controlling and human reproductive protection.