Thermal management has emerged as one of the most significant difficulties in various technologies today, owing to the increasing demand for faster processing rates and the continual shrinking of the physical dimensions of the devices. There are numerous techniques to increase the thermal performance of equipment. Heat pipes are low-cost, passive devices having a simple form, low thermal resistance, high effective thermal conductivity, and high efficiency. Water, methanol, ethylene glycol, and their combinations are the most widely utilized working fluids in these heat pipes. However, they are poor heat transmission fluids. The heat transmission performance of a fluid can be considerably increased by suspending nano-sized particles in it. Experiments are conducted on this heat pipe to improve performance using a Hybrid nanofluid. The main objective of this research is to evaluate the heat transfer performance of a heat pipe using various working fluids such as de-ionized water (DI water), aluminum oxide (Al2O3) nanofluid, and hybrid nanofluid (Al2O3 + CuO). The heat pipe's performance was examined with DI water, Al2O3 nanofluid, and a hybrid nanofluid at various heat inputs (20 W, 40 W, 60 W, 80 W and 100 W). Higher thermal conductivity, stability, and enhanced heat transfer rates can be achieved by the use of hybrid nanofluids. At a 100 W heat input to the heat pipe, the results demonstrate that the heat transfer coefficient and effective thermal conductivity of the hybrid nanofluid are 32 % higher and the thermal resistance is 24 % lower than those of the Al2O3 nanofluid.