Mechanism-based population pharmacokinetic and pharmacodynamic modeling of intravenous and intranasal dexmedetomidine in healthy subjects

被引：0
|
作者：
Heedoo Yoo
Timo Iirola
Sanna Vilo
Tuula Manner
Riku Aantaa
Maria Lahtinen
Mika Scheinin
Klaus T. Olkkola
William J. Jusko
机构：
[1] State University of New York at Buffalo,Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, 404 Kapoor Hall
[2] University of Turku and Turku University Hospital,Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine
[3] University of Turku and Unit of Clinical Pharmacology,Department of Pharmacology, Drug Development and Therapeutics
[4] University of Helsinki and Helsinki University Hospital,Department of Anaesthesiology, Intensive Care and Pain Medicine
来源：
European Journal of Clinical Pharmacology | 2015年 / 71卷
关键词：
Dexmedetomidine; Mechanism-based modeling; Population pharmacokinetics; Pharmacodynamics; α; -adrenoceptor agonist; Norepinephrine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：1197 / 1207
页数：10
相关论文
共 50 条
  • [1] Mechanism-based population pharmacokinetic and pharmacodynamic modeling of intravenous and intranasal dexmedetomidine in healthy subjects
    Yoo, Heedoo
    Iirola, Timo
    Vilo, Sanna
    Manner, Tuula
    Aantaa, Riku
    Lahtinen, Maria
    Scheinin, Mika
    Olkkola, Klaus T.
    Jusko, William J.
    EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2015, 71 (10) : 1197 - 1207
  • [2] Pharmacokinetic and pharmacodynamic study of intranasal and intravenous dexmedetomidine
    Li, A.
    Yuen, V. M.
    Goulay-Dufay, S.
    Sheng, Y.
    Standing, J. F.
    Kwok, P. C. L.
    Leung, M. K. M.
    Leung, A. S.
    Wong, I. C. K.
    Irwin, M. G.
    BRITISH JOURNAL OF ANAESTHESIA, 2018, 120 (05) : 960 - 968
  • [3] Intranasal dexmedetomidine in healthy beagles: An echocardiographic and pharmacokinetic/pharmacodynamic study
    Santangelo, B.
    Harel, M.
    Fourel, I.
    Micieli, F.
    Cataldi, M.
    Segard-Weisse, E.
    Portier, K.
    VETERINARY JOURNAL, 2019, 251
  • [4] Mechanism-based pharmacokinetic - Pharmacodynamic modeling of bendazac lysine
    Luo, Jianping
    Yu, Junxian
    Zhang, Yindi
    Chen, Xaoxiang
    Shen, Jianping
    ACTA PHARMACOLOGICA SINICA, 2006, 27 : 204 - 204
  • [5] Mechanism-based pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of buprenorphine in healthy volunteers
    Yassen, Ashraf
    Olofsen, Erik
    Romberg, Raymonda
    Sarton, Elise
    Danhof, Meindert
    Dahan, Albert
    ANESTHESIOLOGY, 2006, 104 (06) : 1232 - 1242
  • [6] Mechanism-based pharmacokinetic–pharmacodynamic modeling of antimicrobial drug effects
    David Czock
    Frieder Keller
    Journal of Pharmacokinetics and Pharmacodynamics, 2007, 34 : 727 - 751
  • [7] Mechanism-Based Pharmacokinetic–Pharmacodynamic Modeling—A New Classification of Biomarkers
    Meindert Danhof
    Gunnar Alvan
    Svein G. Dahl
    Jochen Kuhlmann
    Gilles Paintaud
    Pharmaceutical Research, 2005, 22 : 1432 - 1437
  • [8] Population Pharmacokinetic/Pharmacodynamic Analysis of Intravenous Zanamivir in Healthy and Hospitalized Subjects with Influenza
    Zuo, Peiying
    Collins, Jon
    Shortino, Denise
    Watson, Helen
    Roberts, Grace
    Peppercorn, Amanda
    Hossain, Mohammad
    JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, 2016, 43 : S112 - S112
  • [9] MECHANISM-BASED PHARMACODYNAMIC MODELING
    LEVY, G
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 1994, 56 (04) : 356 - 358
  • [10] Pharmacokinetic/pharmacodynamic modeling of pegfilgrastim in healthy subjects
    Roskos, Lorin K.
    Lum, Peggy
    Lockbaum, Pamela
    Schwab, Gisela
    Yang, Bing-Bing
    JOURNAL OF CLINICAL PHARMACOLOGY, 2006, 46 (07): : 747 - 757
12345