Standardized determination of tumor-infiltrating lymphocytes in breast cancer. A prognostic marker for histological diagnosis

被引：5
|
作者：
Denkert, C. [1 ,2 ]
Loibl, S. [3 ]
Budczies, J. [1 ,5 ]
Wienert, S. [1 ,4 ]
Klauschen, F. [1 ]
机构：
[1] Univ Med Berlin, Inst Pathol Charite, Charitepl 1, D-10117 Berlin, Germany
[2] Standort Berlin, DKTK, Berlin, Germany
[3] German Breast Grp, Neu Isenburg, Germany
[4] VMscope GmbH, Berlin, Germany
[5] Heidelberg Univ, Inst Pathol, Heidelberg, Germany
来源：
PATHOLOGE | 2018年 / 39卷 / 06期
关键词：
Biomarkers; Breast neoplasms; Neoadjuvant therapy; Prognosis; Immune infiltrate; INTEROBSERVER AGREEMENT; INTERNATIONAL KI67; FREE SURVIVAL; SOLID TUMORS; CELL-DEATH; PATHOLOGISTS; CHEMOTHERAPY; TRASTUZUMAB; CARCINOMA; IMMUNE;
D O I：
10.1007/s00292-018-0530-y
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
BackgroundTumor-infiltrating lymphocytes (TILs) have been identified as prognostic parameter in breast cancer.ObjectivesThe aim of this review article is to provide an overview on the clinical and analytical validation of TILs in breast cancer.Materials and methodsSummary of international guidelines of the TIL working group as well as clinical and translational studies.Results, ConclusionsBreast carcinomas with ahigh TIL level have an improved response to neoadjuvant chemotherapy. Triple-negative and HER2-positive carcinomas with increased TIL levels have improved survival. TILs are anew prognostic biomarker for routine histopathological diagnosis.
引用
收藏
页码：520 / 531
页数：12
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