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Univ Penn, Perelman Sch Med, Dept Anesthesiol & Crit Care, Div Cardiothorac Anesthesiol, 11 John Morgan Bldg,3620 Hamilton Walk, Philadelphia, PA 19104 USA Univ Penn, Perelman Sch Med, Dept Anesthesiol & Crit Care, Div Cardiothorac Anesthesiol, 11 John Morgan Bldg,3620 Hamilton Walk, Philadelphia, PA 19104 USA