Small-molecule inhibition of HIV-1 Vif

被引：0
|
作者：
Robin Nathans
Hong Cao
Natalia Sharova
Akbar Ali
Mark Sharkey
Ruzena Stranska
Mario Stevenson
Tariq M Rana
机构：
[1] Chemical Biology Program,Department of Biochemistry and Molecular Pharmacology
[2] University of Massachusetts Medical School,undefined
[3] Worcester,undefined
[4] Massachusetts 01605,undefined
[5] USA.,undefined
[6] Molecular Medicine Program,undefined
[7] University of Massachusetts Medical School,undefined
[8] Present address: Program for RNA Biology,undefined
[9] Sanford Children's Health Research Center,undefined
[10] Burnham Institute for Medical Research,undefined
[11] 10901 North Torrey Pines Road,undefined
[12] La Jolla,undefined
[13] California 92037,undefined
[14] USA.,undefined
来源：
Nature Biotechnology | 2008年 / 26卷
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学科分类号：
摘要：
The HIV-1 protein Vif, which promotes degradation of the host cell's antiviral APOBEC3 proteins, has yet to be targeted for therapeutic intervention. Nathans et al. use a high-throughput fluorescence screen to identify a small molecule that inhibits HIV replication in cultured cells by antagonizing Vif in an APOBEC3-dependent manner.
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页码：1187 / 1192
页数：5
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