Effects of selenium deficiency on the rat myocardial protein pattern – investigation by two-dimensional gel electrophoresis

被引:1
|
作者
Vera Regitz-Zagrosek
Antonius Kyriakopoulos
Klaus-Peter Pleißner
Peter Jungblut
Eckart Fleck
Dietrich Behne
机构
[1] Innere Medizin/Kardiologie,
[2] Humboldt Universität Charité,undefined
[3] Campus Virchow-Klinikum und Deutsches Herzzentrum Berlin,undefined
[4] Augustenburger Platz 1,undefined
[5] D-13353 Berlin,undefined
[6] E-mail: Zagrosek@dhzb.de,undefined
[7] Hahn-Meitner-Institut Berlin,undefined
[8] Abt. “Spurenelemente in Gesundheit und Ernährung”,undefined
[9] Glienicker Str. 100 D-14109 Berlin,undefined
[10] Max-Planck-Institut für Infektionsbiologie,undefined
[11] Monbijoustr. 2,undefined
[12] D-10117 Berlin,undefined
来源
关键词
Key words Rat – myocardium – selenium deficiency – two-dimensional gel electrophoresis – computer-assisted image analysis – protein identification;
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学科分类号
摘要
Dietary selenium deficiency represents an etiological factor in “Keshan disease”, a distinct form of an endemic cardiomyopathy. The biochemical effects of selenium depletion in the myocardium are, however, not yet known. Therefore, we investigated the changes in the myocardial protein pattern in rats after long-term selenium deficiency.
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页码:199 / 207
页数:8
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