An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers

被引：0

作者：

Kin Chan

Steven A Roberts

Leszek J Klimczak

Joan F Sterling

Natalie Saini

Ewa P Malc

Jaegil Kim

David J Kwiatkowski

David C Fargo

Piotr A Mieczkowski

Gad Getz

Dmitry A Gordenin

机构：

[1] Genome Integrity and Structural Biology Laboratory,Department of Genetics

[2] National Institute of Environmental Health Sciences,Department of Medicine

[3] US National Institutes of Health,Department of Pathology

[4] School of Molecular Biosciences,undefined

[5] Washington State University,undefined

[6] Integrative Bioinformatics Support Group,undefined

[7] National Institute of Environmental Health Sciences,undefined

[8] US National Institutes of Health,undefined

[9] Lineberger Comprehensive Cancer Center,undefined

[10] University of North Carolina,undefined

[11] Broad Institute of MIT and Harvard,undefined

[12] Brigham and Women's Hospital,undefined

[13] Harvard Medical School,undefined

[14] Massachusetts General Hospital,undefined

[15] Harvard Medical School,undefined

来源：

Nature Genetics | 2015年 / 47卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Dmitry Gordenin and colleagues use a yeast reporter strain to identify distinct mutagenic signatures for the cytosine deaminases APOBEC3A and APOBEC3B. They find that cancer samples with APOBEC3A-like mutation signatures have greater than tenfold more APOBEC signature mutations than those with APOBEC3B-like signatures.

引用

页码：1067 / 1072

页数：5

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