We develop and use mathematical models that describe changes in the South African population over the last decades, brought on by HIV and AIDS. We do not model all the phases in HIV progression but rather, we show that a relatively simple model is sufficient to represent the data and allows us to investigate important aspects of HIV infection: firstly, we are able to investigate the effect of awareness on the prevalence of HIV and secondly, it enables us to make a comparison between South Africa and Botswana. A comparison is made between two models: a model that does not reflect awareness of the devastating impact of HIV and AIDS, and a model with an added psychological awareness factor. Both models are fitted to data that reflects the incidence of HIV and AIDS within South Africa. This allows us to examine the impact of psychological awareness. We show that inclusion of the effect of awareness is absolutely necessary to arrive at a model description that satisfactorily fits the available HIV and AIDS data for South Africa. We also show that a relatively simple modelling of awareness (as opposed to more complex mathematical techniques that have been used in past studies) is sufficient to accurately describe the observed patterns in the data. Even though awareness alone is not sufficient to eradicate any disease and other control strategies should be explored and implemented concurrently with educational campaigns, we are able to conclude (through thorough model analyses procedures) that the current level of awareness in South Africa is far below the level that is effectively required to eradicate HIV from the South African population. The awareness model is also fitted to HIV-related data for Botswana and we compare the results with the South African case. Though the effect of awareness is currently estimated at a much higher level in Botswana, other factors such as poorer health care and cultural differences may play a role in limiting the ability of awareness to combat HIV in Botswana.
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North West Univ, Dept Math & Appl Math, ZA-2531 Potchefstroom, South AfricaNorth West Univ, Dept Math & Appl Math, ZA-2531 Potchefstroom, South Africa
Spoelstra, J.
Hemerik, L.
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Wageningen Univ, Dept Math & Stat Methods, NL-6700 AC Wageningen, NetherlandsNorth West Univ, Dept Math & Appl Math, ZA-2531 Potchefstroom, South Africa
Hemerik, L.
Molenaar, J.
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Wageningen Univ, Dept Math & Stat Methods, NL-6700 AC Wageningen, NetherlandsNorth West Univ, Dept Math & Appl Math, ZA-2531 Potchefstroom, South Africa
机构:
Human Sci Res Council, Demog Unit, Social Aspects HIV AIDS & Hlth program, Pretoria, South AfricaHuman Sci Res Council, Demog Unit, Social Aspects HIV AIDS & Hlth program, Pretoria, South Africa
机构:
Imperial Coll London, MRC Ctr Global Infect Dis Anal, Sch Publ Hlth, London, EnglandImperial Coll London, MRC Ctr Global Infect Dis Anal, Sch Publ Hlth, London, England
Boily, Marie-Claude
Barnabas, Ruanne, V
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Harvard Med Sch, Massachusetts Gen Hosp, Div Infect Dis, Boston, MA USAImperial Coll London, MRC Ctr Global Infect Dis Anal, Sch Publ Hlth, London, England
Barnabas, Ruanne, V
Ronn, Minttu M.
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Harvard TH Chan Sch Publ Hlth, Dept Global Hlth & Populat, Boston, MA USAImperial Coll London, MRC Ctr Global Infect Dis Anal, Sch Publ Hlth, London, England
Ronn, Minttu M.
Bayer, Cara J.
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Univ Washington, Dept Epidemiol, Seattle, WA USA
Univ Washington, Dept Global Hlth, Seattle, WA USAImperial Coll London, MRC Ctr Global Infect Dis Anal, Sch Publ Hlth, London, England
Bayer, Cara J.
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van Schalkwyk, Cari
Soni, Nirali
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Imperial Coll London, MRC Ctr Global Infect Dis Anal, Sch Publ Hlth, London, EnglandImperial Coll London, MRC Ctr Global Infect Dis Anal, Sch Publ Hlth, London, England
Soni, Nirali
Rao, Darcy W.
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Univ Washington, Dept Epidemiol, Seattle, WA USA
Univ Washington, Dept Global Hlth, Seattle, WA USAImperial Coll London, MRC Ctr Global Infect Dis Anal, Sch Publ Hlth, London, England
Rao, Darcy W.
Staadegaard, Lisa
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Imperial Coll London, MRC Ctr Global Infect Dis Anal, Sch Publ Hlth, London, EnglandImperial Coll London, MRC Ctr Global Infect Dis Anal, Sch Publ Hlth, London, England
Staadegaard, Lisa
Liu, Gui
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Univ Washington, Dept Epidemiol, Seattle, WA USA
Univ Washington, Dept Global Hlth, Seattle, WA USAImperial Coll London, MRC Ctr Global Infect Dis Anal, Sch Publ Hlth, London, England
Liu, Gui
Silhol, Romain
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Imperial Coll London, MRC Ctr Global Infect Dis Anal, Sch Publ Hlth, London, EnglandImperial Coll London, MRC Ctr Global Infect Dis Anal, Sch Publ Hlth, London, England
Silhol, Romain
Brisson, Marc
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CHU Quebec, Ctr Rech, Quebec City, PQ, Canada
Univ Laval, Dept Med Sociale & Prevent, Quebec City, PQ, CanadaImperial Coll London, MRC Ctr Global Infect Dis Anal, Sch Publ Hlth, London, England
Brisson, Marc
Johnson, Leigh F.
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Univ Cape Town, Ctr Infect Dis Epidemiol & Res, Cape Town, South AfricaImperial Coll London, MRC Ctr Global Infect Dis Anal, Sch Publ Hlth, London, England
Johnson, Leigh F.
Bloem, Paul
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WHO, Dept Immunizat Vaccines & Biol, Dept Global HIV, Geneva, SwitzerlandImperial Coll London, MRC Ctr Global Infect Dis Anal, Sch Publ Hlth, London, England
Bloem, Paul
Gottlieb, Sami
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WHO, Dept Sexual & Reprod Hlth & Res, Geneva, SwitzerlandImperial Coll London, MRC Ctr Global Infect Dis Anal, Sch Publ Hlth, London, England
Gottlieb, Sami
Broutet, Nathalie
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WHO, Dept Sexual & Reprod Hlth & Res, Geneva, SwitzerlandImperial Coll London, MRC Ctr Global Infect Dis Anal, Sch Publ Hlth, London, England
Broutet, Nathalie
Dalal, Shona
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机构:Imperial Coll London, MRC Ctr Global Infect Dis Anal, Sch Publ Hlth, London, England