Electrical activity of the neocortex in adult rats after prenatal hypoxia and in epilepsy model

被引：0
|
作者：
D. S. Kalinina
A. B. Vol’nova
O. S. Alekseeva
I. A. Zhuravin
机构：
[1] Russian Academy of Sciences,Sechenov Institute of Evolutionary Physiology and Biochemistry
[2] St. Petersburg State University,St. Petersburg State Pediatric Medical University
[3] Ministry of Health of the Russian Federation,undefined
来源：
Journal of Evolutionary Biochemistry and Physiology | 2016年 / 52卷
关键词：
4-aminopyridine; spectral power; ECoG; prenatal hypoxic stress;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Changes in electrical activity of the neocortex after prenatal hypoxia (day 14 of embryogenesis, E14, 7% O2 for 3 h) and intracortical microinjection of epileptogenic 4-aminopyridine (4-AP) were studied in adult (3-month-old) rats. The frequency–time parameters of electrocorticogram (ECoG) were analyzed during sleep and wakefulness as well as in a model of 4-AP-induced spike-wave discharge (SWD) epileptiform activity. The results showed that in rats exposed to prenatal hypoxia the theta rhythm had a lower frequency while sleep spindles displayed a lower spectral power in the low-frequency range as compared to the control group. In rats with prenatal pathology, there was revealed a delayed onset of epileptiform activity and a shifted frequency distribution of the SWD spectral power induced by 4-AP.
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页码：352 / 358
页数：6
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