Randomized phase III clinical trial comparing the combination of capecitabine and oxaliplatin (CAPOX) with the combination of 5-fluorouracil, leucovorin and oxaliplatin (modified FOLFOX6) as adjuvant therapy in patients with operated high-risk stage II or stage III colorectal cancer

被引:0
|
作者
Dimitrios Pectasides
Vasilios Karavasilis
George Papaxoinis
Georgia Gourgioti
Thomas Makatsoris
Georgia Raptou
Eleni Vrettou
Joseph Sgouros
Epaminontas Samantas
George Basdanis
Pavlos Papakostas
Dimitrios Bafaloukos
Vassiliki Kotoula
Haralambos P. Kalofonos
Chrisoula D. Scopa
George Pentheroudakis
George Fountzilas
机构
[1] “Hippokration” Hospital,Oncology Section, Second Department of Internal Medicine
[2] Aristotle University of Thessaloniki School of Medicine,Department of Medical Oncology, “Papageorgiou” Hospital
[3] Section of Biostatistics,Division of Oncology, Department of Medicine
[4] Hellenic Cooperative Oncology Group,Department of Pathology
[5] Data Office,Third Department of Medical Oncology
[6] University Hospital,First Propaedeutic Department of Surgery, “AHEPA” Hospital
[7] University of Patras Medical School,Department of Medical Oncology
[8] Aristotle University of Thessaloniki School of Medicine,First Department of Medical Oncology
[9] “Agii Anargiri” Cancer Hospital,Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research
[10] Aristotle University of Thessaloniki School of Medicine,Department of Pathology
[11] “Hippokration” Hospital,Department of Medical Oncology
[12] “Metropolitan” Hospital,undefined
[13] Aristotle University of Thessaloniki School of Medicine,undefined
[14] University Hospital,undefined
[15] University of Patras Medical School,undefined
[16] Ioannina University Hospital,undefined
来源
BMC Cancer | / 15卷
关键词
Colorectal cancer; Adjuvant chemotherapy; Modified FOLFOX6; Capecitabine; Oxaliplatin; Prognosis; KRAS; Microsatellite instability;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [1] Randomized phase III clinical trial comparing the combination of capecitabine and oxaliplatin (CAPOX) with the combination of 5-fluorouracil, leucovorin and oxaliplatin (modified FOLFOX6) as adjuvant therapy in patients with operated high-risk stage II or stage III colorectal cancer
    Pectasides, Dimitrios
    Karavasilis, Vasilios
    Papaxoinis, George
    Gourgioti, Georgia
    Makatsoris, Thomas
    Raptou, Georgia
    Vrettou, Eleni
    Sgouros, Joseph
    Samantas, Epaminontas
    Basdanis, George
    Papakostas, Pavlos
    Bafaloukos, Dimitrios
    Kotoula, Vassiliki
    Kalofonos, Haralambos P.
    Scopa, Chrisoula D.
    Pentheroudakis, George
    Fountzilas, George
    BMC CANCER, 2015, 15
  • [2] Pilot study of the combination of capecitabine plus oxaliplatin as adjuvant therapy for patients with stage III and high risk stage II colon cancer
    Olier, C.
    Reyna, C.
    Aramendia, J. M.
    Rodriguez, J.
    Viudez, A.
    Chopitea, A.
    Garcia-Foncillas, J.
    JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (15)
  • [3] Adjuvant 5-Fluorouracil/leucovorin, capecitabine, and oxaliplatin-related regimens for stage II/III colon cancer patients 66 years or older
    Jones, Emily
    Duan, Zhigang
    Nguyen, Thinh T.
    Giordano, Sharon H.
    Zhao, Hui
    CANCER MEDICINE, 2023, 12 (03): : 2389 - 2406
  • [4] Sorafenib in Combination with Oxaliplatin, Leucovorin, and Fluorouracil (Modified FOLFOX6) as First-line Treatment of Metastatic Colorectal Cancer: The RESPECT Trial
    Tabernero, Josep
    Garcia-Carbonero, Rocio
    Cassidy, James
    Sobrero, Alberto
    Van Cutsem, Eric
    Koehne, Claus-Henning
    Tejpar, Sabine
    Gladkov, Oleg
    Davidenko, Irina
    Salazar, Ramon
    Vladimirova, Liubov
    Cheporov, Sergey
    Burdaeva, Olga
    Rivera, Fernando
    Samuel, Leslie
    Bulavina, Irina
    Potter, Vanessa
    Chang, Yu-Lin
    Lokker, Nathalie A.
    O'Dwyer, Peter J.
    CLINICAL CANCER RESEARCH, 2013, 19 (09) : 2541 - 2550
  • [5] A multicenter phase 2 clinical trial testing a combination of oxaliplatin, bolus 5-fluorouracil, leucovorin and capecitabine in patients with metastatic colorectal cancer (MCRC)
    LoConte, N. K.
    Holen, K. D.
    Eickhoff, J.
    Dzelak, T.
    Richie, K.
    Teeter, K.
    Warren, D.
    Jumonville, A. J.
    Kwong, R. W.
    Mulkerin, D. L.
    JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (18)
  • [6] Phase I clinical trial of lenalidomide in combination with 5-fluorouracil, leucovorin, and oxaliplatin in patients with advanced cancer
    Said, Rabih
    Ye, Yang
    Hong, David S.
    Naing, Aung
    Falchook, Gerald
    Fu, Siqing
    Wheler, Jennifer J.
    Piha-Paul, Sarina
    Tsimberidou, Apostolia-Maria
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2016, 77 (03) : 575 - 581
  • [7] Phase I study of oxaliplatin in combination with capecitabine and radiotherapy as adjuvant treatment for stage II and III rectal cancer
    Jin, J.
    Li, Y. X.
    Wang, W. H.
    Liu, Y. P.
    Wang, K.
    Fang, H.
    Zhou, Z. X.
    Zhou, A. P.
    Wang, J. W.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2007, 69 (03): : S284 - S285
  • [8] Phase I clinical trial of lenalidomide in combination with 5-fluorouracil, leucovorin, and oxaliplatin in patients with advanced cancer
    Rabih Said
    Yang Ye
    David S. Hong
    Aung Naing
    Gerald Falchook
    Siqing Fu
    Jennifer J. Wheler
    Sarina Piha-Paul
    Apostolia-Maria Tsimberidou
    Cancer Chemotherapy and Pharmacology, 2016, 77 : 575 - 581
  • [9] Phase III study of 5-fluorouracil/leucovorin plus oxaliplatin versus capecitabine plus oxaliplatin as first line therapy in patients with advanced colorectal cancer (ACRC)
    Porschen, R
    Arkenau, T
    Kubicka, S
    Schmoll, HJ
    Seufferlein, T
    Graeven, U
    Grothey, A
    GASTROENTEROLOGY, 2005, 128 (04) : A438 - A438
  • [10] Microsatellite Instability was not Associated with Survival in Stage III Colon Cancer Treated with Adjuvant Chemotherapy of Oxaliplatin and Infusional 5-Fluorouracil and Leucovorin (FOLFOX)
    Jeong Eun Kim
    Yong Sang Hong
    Hwa Jung Kim
    Kyu-pyo Kim
    Sun Young Kim
    Seok-Byung Lim
    In Ja Park
    Chan Wook Kim
    Yong Sik Yoon
    Chang Sik Yu
    Jin Cheon Kim
    Ji Hun Kim
    Tae Won Kim
    Annals of Surgical Oncology, 2017, 24 : 1289 - 1294