Protein phosphatase-2A is activated in pig brain following cardiac arrest and resuscitation

被引：0
|
作者：
Tao T. Zhang
Jimcy Platholi
Paul M. Heerdt
Hugh C. Hemmings
H. Y. L. Tung
机构：
[1] Weill Medical College of Cornell University,Institute for Neuronal Cell Signaling, Department of Anesthesiology
[2] Weill Medical College of Cornell University,Department of Pharmacology
[3] Weill Medical College of Cornell University,Laboratory of Neurobiochemistry, Institute for Neuronal Cell Signaling, Department of Anesthesiology
来源：
Metabolic Brain Disease | 2008年 / 23卷
关键词：
Apoptosis; Necrotic cell death; Inhibitor-1; Inhibitor-2; Okadaic acid; Tautomycin;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Protein phosphatase-2A (PP-2A) interacts with several regulators of cell death pathways and is therefore a potential component of signaling pathways linking global cerebral ischemia to cell death. Using a novel procedure to quantify PP-2A activity, we find that cardiac arrest with resuscitation and reperfusion leads to activation of PP-2A by 1.6-fold in pig brain extract and by 3.4-fold after partial purification of PP-2A. This is the first demonstration of PP-2A activation in a clinically relevant model of transient global cerebral ischemia. These results suggest that inhibition of PP-2A activity may be neuroprotective in global cerebral ischemia.
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页码：95 / 104
页数：9
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