Efficiency analysis of clearance of two types of exogenous iron from the rat brain by Mössbauer spectroscopy

被引：0
|
作者：
D. M. Polikarpov
V. M. Cherepanov
R. R. Gabbasov
M. A. Chuev
I. N. Mischenko
V. A. Korshunov
V. Y. Panchenko
机构：
[1] National Research Centre,Russian Institute of Physics and Technology
[2] “Kurchatov Institute”,Institute of Higher Nervous Activity and Neurophysiology
[3] Russian National Research,undefined
[4] Medical University,undefined
[5] Russian Academy of Sciences,undefined
[6] Russian Academy of Sciences,undefined
来源：
Hyperfine Interactions | 2013年 / 218卷
关键词：
Mössbauer spectroscopy; Magnetic nanoparticles; Brain;
D O I：
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学科分类号：
摘要：
Fe3O4 based ferrofluid was injected transcranially in the ventricle of the rat brain. At 3 months after the injection the rat was sacrificed and the brain was investigated by Mössbauer spectroscopy and histological Perls Prussian blue method. Joint analysis of histological and Mössbauer data confirms that superparamagnetic nanoparticles Fe3O4, which constituted about 91 % of the iron of the ferrofluid, were cleared from the brain, while the concomitant chemical compound containing ferric ion in the high-spin state, remains intact.
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页码：83 / 88
页数：5
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