Synthesis, structure, and biological activity of the cis-[4-amino-2,2,6,6-tetramethylpiperidine-N,N′]dichloropalladium(ii) complex

被引：0
|
作者：
B. S. Fedorov
M. A. Fadeev
G. I. Kozub
N. I. Golovina
A. N. Utenyshev
G. V. Shilov
S. M. Aldoshin
N. P. Konovalova
T. E. Sashenkova
T. A. Kondrat’eva
机构：
[1] Russian Academy of Sciences,Institute of Problems of Chemical Physics
来源：
Russian Chemical Bulletin | 2013年 / 62卷
关键词：
synthesis; complexation with PdCl; metal complex; -[4-amino-2,2,6,6-tetramethylpiperidine-; ]dichloropalladium(; ); chelate; X-ray diffraction study; antimetastatic activity; toxicity;
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学科分类号：
摘要：
A previously unknown palladium complex was synthesized by the reaction of 4-amino-2,2,6,6-tetramethylpiperidine with PdCl2. The X-ray diffraction study showed that the complex formed by 4-amino-2,2,6,6-tetramethylpiperidine with PdCl2 is a chelate, in which the bidentate ligand adopts a boat conformation with the nitrogen atoms occupying cis positions at the palladium atom. The resulting cis-[4-amino-2,2,6,6-tetramethylpiperidine-N,N′]dichloro-palladium(ii) complex exhibits strong antimetastatic activity against experimental B16 melanoma at moderate toxicity.
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页码：572 / 574
页数：2
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