Effect of Acetylation of Histone H4 on Communication in Chromatin

被引：0
|
作者：
Nizovtseva E.V. [1 ]
Gerasimova N.S. [2 ]
Studitsky V.M. [1 ,2 ]
机构：
[1] Cancer Epigenetics Team, Fox Chase Cancer Center, Philadelphia, 19111, PA
[2] Bioengineering Department, Biological Faculty, Moscow State University, Moscow
来源：
Moscow University Biological Sciences Bulletin | 2019年 / 74卷 / 4期
关键词：
acetylation; chromatin; enhancers; histones; modifications; regulation; transcription;
D O I：
10.3103/S0096392519040114
中图分类号：
学科分类号：
摘要：
Abstract: Long-distance interaction plays an important role in the regulation of eukaryotic genes. Chromatin structure is involved in the process, but the role of histone modifications has not been studied. In the present work, the role of acetylation Н4K16 (Н4K16-Ac) to enhancer-promoter communication (EPC) was analyzed. This modification is associated with euchromatin and is involved in the decompaction of chromatin fibers. We have shown that the effect of H4K16-Ac on EPC in vitro depends on the level of chromatin assembly. EPC in chromatin, which lacks nucleosomes at random positions on DNA, is inhibited in the presence of H4K16-Aс. At the same time, EPC in chromatin, in which nucleosomes occupy all available positions on DNA, is somewhat stimulated in the presence of H4K16-Aс. © 2019, Allerton Press, Inc.
引用
收藏
页码：246 / 249
页数：3
相关论文
共 50 条
  • [1] Acetylation of histone H4 in complex structural transitions of spermiogenic chromatin
    Kurtz, Kathryn
    Martinez-Soler, Fina
    Ausio, Juan
    Chiva, Manel
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2007, 102 (06) : 1432 - 1441
  • [2] Histone H4 acetylation required for chromatin decompaction during DNA replication
    Ruan, Kun
    Yamamoto, Takaharu G.
    Asakawa, Haruhiko
    Chikashige, Yuji
    Kimura, Hiroshi
    Masukata, Hisao
    Haraguchi, Tokuko
    Hiraoka, Yasushi
    SCIENTIFIC REPORTS, 2015, 5
  • [3] Histone H4 acetylation required for chromatin decompaction during DNA replication
    Kun Ruan
    Takaharu G. Yamamoto
    Haruhiko Asakawa
    Yuji Chikashige
    Hiroshi Kimura
    Hisao Masukata
    Tokuko Haraguchi
    Yasushi Hiraoka
    Scientific Reports, 5
  • [4] Early histone H4 acetylation during chromatin remodeling in equine spermatogenesis
    Ketchum, Chelsea C.
    Larsen, Casey D.
    McNeil, Alexis
    Meyer-Ficca, Mirella L.
    Meyer, Ralph G.
    BIOLOGY OF REPRODUCTION, 2018, 98 (01) : 115 - 129
  • [5] The acetylation landscape of the H4 histone tail
    Papoian, G. A.
    Winogradoff, D.
    Echeverria, I.
    EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2015, 44 : S229 - S229
  • [6] Dynamic chromatin association of IκBα is regulated by acetylation and cleavage of histone H4
    Marruecos, Laura
    Bertran, Joan
    Alvarez-Villanueva, Daniel
    Carmen Mulero, Maria
    Guillen, Yolanda
    Palma, Luis G.
    Floor, Martin
    Vert, Anna
    Arce-Gallego, Sara
    Pecharroman, Irene
    Batlle, Laura
    Villa-Freixa, Jordi
    Ghosh, Gourisankar
    Bigas, Anna
    Espinosa, Lluis
    EMBO REPORTS, 2021, 22 (08)
  • [7] The Acetylation Landscape of the H4 Histone Tail
    Winogradoff, David
    Echeverria, Ignacia
    Papoian, Garegin
    BIOPHYSICAL JOURNAL, 2015, 108 (02) : 388A - 388A
  • [8] Probing the acetylation code of histone H4
    Lang, Diana
    Schuemann, Michael
    Gelato, Kathy
    Fischle, Wolfgang
    Schwarzer, Dirk
    Krause, Eberhard
    PROTEOMICS, 2013, 13 (20) : 2989 - 2997
  • [9] Monitoring the effect of belinostat in solid tumors by histone H4 acetylation
    Marquard, Lena
    Petersen, Kamille Dumong
    Persson, Morten
    Hoff, Kirsten Damgaard
    Jensen, Peter Buhl
    Sehested, Maxwell
    APMIS, 2008, 116 (03) : 231 - 232
  • [10] Transcriptional regulation by the chromatin structural change through the acetylation of histone H4 lysine 16
    Suka, N
    NIPPON NOGEIKAGAKU KAISHI-JOURNAL OF THE JAPAN SOCIETY FOR BIOSCIENCE BIOTECHNOLOGY AND AGROCHEMISTRY, 2004, 78 (07): : 649 - 651
12345