Methotrexate BAFFles anti-drug antibodies

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Bruce N. Cronstein
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[1] New York University School of Medicine,
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Combining TNF inhibition with methotrexate treatment is an effective therapeutic approach for patients with rheumatoid arthritis and reduces the likelihood of the patient developing ‘resistance’ to the TNF inhibitor. But how does methotrexate suppress the production of anti-drug antibodies and how can we tell which patients will develop resistance?
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页码:505 / 506
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