TGFβ inhibits IL-1 -induced iNOS expression and NO production in immortalized chondrocytes

被引：0
|
作者：
K. Vuolteenaho
T. Moilanen
U. Jalonen
A. Lahti
R. Nieminen
H. M. van Beuningen
P. M. van der Kraan
E. Moilanen
机构：
[1] University of Tampere and Research Unit,The Immunopharmacological Research Group Medical School
[2] Tampere University Hospital,Laboratory of Experimental Rheumatology
[3] Coxa Hospital for Joint Replacement,undefined
[4] University Medical Center Nijmegen,undefined
来源：
Inflammation Research | 2005年 / 54卷
关键词：
Cartilage; Chondrocytes; Nitric oxide; Osteoarthritis; Transforming growth factor beta;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Objective: The balance between anti-inflammatory (e.g. TGFβ) and proinflammatory cytokines (e.g. IL-1 and TNFα), regulates destructive processes in OA cartilage. IL-1 and TNFα enhance nitric oxide (NO) production in OA cartilage through the inducible nitric oxide synthase (iNOS) pathway and NO mediates many of the destructive effects of these cytokines. The aim of the present study was to investigate the effects of TGFβ on NO production in immortalized H4 chondrocytes exposed to IL-1.
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页码：420 / 427
页数：7
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