Pediatric non–Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes

被引：0

作者：

Jasmijn D E de Rooij

Cristyn Branstetter

Jing Ma

Yongjin Li

Michael P Walsh

Jinjun Cheng

Askar Obulkasim

Jinjun Dang

John Easton

Lonneke J Verboon

Heather L Mulder

Martin Zimmermann

Cary Koss

Pankaj Gupta

Michael Edmonson

Michael Rusch

Joshua Yew Suang Lim

Katarina Reinhardt

Martina Pigazzi

Guangchun Song

Allen Eng Juh Yeoh

Lee-Yung Shih

Der-Cherng Liang

Stephanie Halene

Diane S Krause

Jinghui Zhang

James R Downing

Franco Locatelli

Dirk Reinhardt

Marry M van den Heuvel-Eibrink

C Michel Zwaan

Maarten Fornerod

Tanja A Gruber

机构：

[1] Erasmus MC–Sophia Children's Hospital,Department of Pediatric Oncology

[2] St. Jude Children's Research Hospital,Department of Oncology

[3] St. Jude Children's Research Hospital,Department of Pathology

[4] St. Jude Children's Research Hospital,Department of Computational Biology

[5] Medical School Hannover,Department of Pediatric Hematology/Oncology

[6] Yong Loo Lin School of Medicine,Department of Pediatrics

[7] National University of Singapore,Department of Pediatric Oncology

[8] University of Duisburg-Essen,Department of Women's and Children's Health

[9] University of Padova,Department of Pediatrics

[10] Cancer Science Institute,Department of Internal Medicine and Yale Comprehensive Cancer Center

[11] National University of Singapore,Department of Laboratory Medicine

[12] Chang Gung Memorial Hospital–Linkou,Department of Pediatric Hematology Oncology

[13] Chang Gung University,Department of Pediatric Oncology

[14] Mackay Memorial Hospital,undefined

[15] Section of Hematology,undefined

[16] Yale University School of Medicine,undefined

[17] Yale University,undefined

[18] University of Pavia,undefined

[19] IRCCS Ospedale Pediatrico Bambino Gesù,undefined

[20] Princess Maxima Center for Pediatric Oncology,undefined

来源：

Nature Genetics | 2017年 / 49卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Franco Locatelli, Dirk Reinhardt, Marry van den Heuvel-Eibrink, C Michel Zwaan, Maarten Fornerod, Tanja Gruber and colleagues report whole-exome and transcriptome sequencing of acute megakaryoblastic leukemia from pediatric and adult patients without Down syndrome (non-DS-AMKL). They find that pediatric non-DS-AMKL can be divided into seven subgroups characterized by chimeric oncogenes with cooperating mutations in epigenetic and kinase signaling genes.

引用

页码：451 / 456

页数：5

共 50 条

[1] Pediatric non-Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes
de Rooij, Jasmijn D. E.
Branstetter, Cristyn
Ma, Jing
Li, Yongjin
Walsh, Michael P.
Cheng, Jinjun
Obulkasim, Askar
Dang, Jinjun
Easton, John
Verboon, Lonneke J.
Mulder, Heather L.
Zimmermann, Martin
Koss, Cary
Gupta, Pankaj
Edmonson, Michael
Rusch, Michael
Lim, Joshua Yew Suang
Reinhardt, Katarina
Pigazzi, Martina
Song, Guangchun
Yeoh, Allen Eng Juh
Shih, Lee-Yung
Liang, Der-Cherng
Halene, Stephanie
Krause, Diane S.
Zhang, Jinghui
Downing, James R.
Locatelli, Franco
Reinhardt, Dirk
van den Heuvel-Eibrink, Marry M.
Zwaan, C. Michel
Fornerod, Maarten
Gruber, Tanja A.
NATURE GENETICS, 2017, 49 (03) : 451 - 456
[2] Genomic Landscape of Pediatric Non-Down's Syndrome Acute Megakaryoblastic Leukemia in China
Wu, Kefei
Liu, Hui
Xie, Yangyang
Liu, Yuhan
Cui, Bowen
Cai, Jiaoyang
Wang, Ronghua
Wang, Yong
Wang, Xiang
Chen, Xiaoxiao
Zhao, Shuang
Liu, Ting
Wang, Han
Wu, Wenyan
Sun, Huiying
Rao, Jian'an
Wang, Lan
Chen, Jing
Chen, Jing
Li, Benshang
Liu, Yu
Hu, Wenting
Shen, Shuhong
BLOOD, 2023, 142
[3] Pediatric Non-Down Syndrome Acute Megakaryoblastic Leukemia With Unusual Immunophenotype
Laxminarayana, Sindhura Lakshmi Koulmane
Kohli, Saksham
Agrohi, Jhalak
Belurkar, Sushma
CUREUS JOURNAL OF MEDICAL SCIENCE, 2023, 15 (03)
[4] Distinct gene signatures of transient and acute megakaryoblastic leukemia in Down syndrome
Lightfoot, J
Hitzler, JK
Zipursky, A
Albert, M
Macgregor, PF
LEUKEMIA, 2004, 18 (10) : 1617 - 1623
[5] Distinct gene signatures of transient and acute megakaryoblastic leukemia in Down syndrome
J Lightfoot
J K Hitzler
A Zipursky
M Albert
P F Macgregor
Leukemia, 2004, 18 : 1617 - 1623
[6] Acute Megakaryoblastic leukemia in Down syndrome
Hitzler, Johann K.
PEDIATRIC BLOOD & CANCER, 2007, 49 (07) : 1066 - 1069
[7] A New Entity?: Distinctive Immunophenotype in Non-Down Syndrome Pediatric Acute Megakaryoblastic Leukemia
Wang, L.
Levenson, B.
Karandikar, N. J.
Emmons, J.
MODERN PATHOLOGY, 2013, 26 : 366A - 366A
[8] THE GENOMIC LANDSCAPE OF PEDIATRIC ACUTE MEGAKARYOBLASTIC LEUKEMIA
Branstetter, Cristyn
de Rooij, Jasmijn
Ma, Jing
Li, Yongjin
Easton, John
Mulder, Heather L.
Rusch, Michael
Lim, Joshua Y. S.
Reinhardt, Katarina
Kham, Shirley
Yeoh, Allen
Shih, Lee-Yung
Liang, Der-Cherng
Rubnitz, Jeffrey
Pui, Ching-Hon
Zhang, Jinghui
Downing, James
Locatelli, Franco
Reinhardt, Dirk
van den Heuvel-Eibrink, Mary
Fornerod, Maarten
Zwaan, C. Michel
Gruber, Tanja
PEDIATRIC BLOOD & CANCER, 2015, 62 : 26 - 27
[9] Non-Coding HOX Fusions in Pediatric Non-Down Syndrome Acute Megakaryoblastic Leukemia
Adriaanse, Fabienne R. S.
Sakurada, Sadie M.
Pruett-Miller, Shondra M.
Stam, Ronald W.
Zwaan, Michel C.
Gruber, Tanja A.
BLOOD, 2019, 134
[10] A New Entity?: Distinctive Immunophenotype in Non-Down Syndrome Pediatric Acute Megakaryoblastic Leukemia
Wang, L.
Levenson, B.
Karandikar, N. J.
Emmons, J.
LABORATORY INVESTIGATION, 2013, 93 : 366A - 366A

← 1 2 3 4 5 →