Rudimentary G-quadruplex–based telomere capping in Saccharomyces cerevisiae

被引：0

作者：

Jasmine S Smith

Qijun Chen

Liliya A Yatsunyk

John M Nicoludis

Mark S Garcia

Ramon Kranaster

Shankar Balasubramanian

David Monchaud

Marie-Paule Teulade-Fichou

Lara Abramowitz

David C Schultz

F Brad Johnson

机构：

[1] University of Pennsylvania School of Medicine,Department of Pathology and Laboratory Medicine

[2] Cell and Molecular Biology Group,Department of Chemistry and Biochemistry

[3] Biomedical Graduate Studies,Department of Chemistry

[4] University of Pennsylvania School of Medicine,undefined

[5] Swarthmore College,undefined

[6] University of Cambridge,undefined

[7] School of Clinical Medicine,undefined

[8] University of Cambridge,undefined

[9] Cancer Research UK,undefined

[10] Cambridge Research Institute,undefined

[11] Li Ka Shing Centre,undefined

[12] Institut Curie,undefined

[13] Section de Recherche,undefined

[14] Centre National de la Recherche Scientifique,undefined

[15] UMR176,undefined

[16] Centre Universitaire Paris XI,undefined

[17] Protein Expression,undefined

[18] Libraries and Molecular Screening Facility,undefined

[19] The Wistar Institute,undefined

来源：

Nature Structural & Molecular Biology | 2011年 / 18卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Telomere capping is essential for genomic integrity. In yeast, a capping complex containing protein Cdc13 protects telomeres from degradation and from the DNA damage repair system. Yeast telomeric repeats can form G-quadruplexes, whose potential capping role is now revealed using Cdc13-impaired strains.

引用

页码：478 / 485

页数：7

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