Regiospecific O-alkylation of 4-polyfluoroalkyl-1H-pyrimidin-2-ones

被引：0
|
作者：
O. G. Khudina
A. E. Ivanova
Ya. V. Burgart
M. I. Kodess
V. I. Saloutin
机构：
[1] Ural Branch of the Russian Academy of Sciences,I. Ya. Postovsky Institute of Organic Synthesis
来源：
Russian Chemical Bulletin | 2011年 / 60卷
关键词：
4-polyfluoroalkylpyrimidin-2-ones; alkylation; organofluorine compounds; epichlorhydrin;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The alkylation of 4-polyfluoroalkylpyrimidin-2-ones with iodomethane, 4-bromobutyl acetate, and epichlorhydrin occurs regiospecifically to form O-regioisomers.
引用
收藏
页码：901 / 905
页数：4
相关论文
共 50 条
  • [1] Regiospecific O-alkylation of 4-polyfluoroalkyl-1H-pyrimidin-2-ones
    Khudina, O. G.
    Ivanova, A. E.
    Burgart, Ya V.
    Kodess, M. I.
    Saloutin, V. I.
    RUSSIAN CHEMICAL BULLETIN, 2011, 60 (05) : 901 - 905
  • [2] Chemoselective O-Alkylation of 4-(Trifluoromethyl)pyrimidin-2(1H)-ones Using 4-(Iodomethyl)pyrimidines
    Mittersteiner, Mateus
    Pereira, Genilson S.
    Wessjohann, Ludger A.
    Bonacorso, Helio G.
    Martins, Marcos A. P.
    Zanatta, Nilo
    ACS OMEGA, 2022, 7 (22): : 18930 - 18939
  • [3] Substituent-Driven SelectiveN-/O-Alkylation of4-(Trihalomethyl)pyrimidin-2(1H)-ones Using Brominated Enones
    Mittersteiner, Mateus
    Pereira, Genilson S.
    Silva, Yuri
    Wessjohann, Ludger A.
    Bonacorso, Helio G.
    Martins, Marcos A. P.
    Zanatta, Nilo
    JOURNAL OF ORGANIC CHEMISTRY, 2022, 87 (07): : 4590 - 4602
  • [4] Regiospecific Bromination of 2-Phenyl-3H-pyrimidin-4-ones
    Zanatta, Nilo
    Fantinel, Leonardo
    Fernandes, Liana da S.
    Wouters, Ana D.
    Bonacorso, Hello G.
    Martins, Marcos A. P.
    SYNTHESIS-STUTTGART, 2008, 21 (21): : 3492 - 3496
  • [5] Alkylation of 2-(Methylsulfanyl)-6-polyfluoroalkyl-pyrimidin-4(3&ITH&IT)-ones with Haloalkanes
    Khudina, O. G.
    Burgart, Ya. V.
    Saloutin, V. I.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2017, 53 (10) : 1556 - 1563
  • [6] O-Alkylation versus C-Alkylation in the Synthesis of 5,6-Dihydro-4H-oxacin-4-ones: Theoretical Approach
    Rosas, Noe
    Salcedo, Roberto
    Sharma, Pankaj
    Arias, Jose Luis
    Arellano, Ivonne
    Cabrera, Armando
    ASIAN JOURNAL OF CHEMISTRY, 2009, 21 (01) : 541 - 548
  • [7] REGIOSPECIFIC ALKYLATION OF TETRONIC ACIDS - FORMATION OF 4-ALKOXY-5H-FURAN-2-ONES AND 2-ALKOXY-5H-FURAN-4-ONES
    WENGEL, AS
    REFFSTRUP, T
    BOLL, PM
    TETRAHEDRON, 1979, 35 (18) : 2181 - 2185
  • [8] N- vs O-alkylation in 2(1H)-quinolinone derivatives
    Guo, ZX
    Cammidge, AN
    McKillop, A
    Horwell, DC
    TETRAHEDRON LETTERS, 1999, 40 (38) : 6999 - 7002
  • [9] THE O-ALKYLATION OF 2-CARBETHOXYCYCLOHEXANONE
    SHEEHAN, JC
    MUMAW, CE
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1950, 72 (05) : 2127 - 2129
  • [10] TETRAHYDROSPIRO([1])BENZOPYRAN-2,4'(1'H)-PYRIMIDIN)-2'(3'H)-ONES
    ZIGEUNER, G
    KORSATKO, W
    FUCHSGRUBER, A
    MONATSHEFTE FUR CHEMIE, 1976, 107 (06): : 1355 - 1359
12345