Small-molecule HDAC and Akt inhibitors suppress tumor growth and enhance immunotherapy in multiple myeloma

被引：0
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作者：
Mitsuhito Hirano
Yoichi Imai
Yuta Kaito
Takahiko Murayama
Kota Sato
Tadao Ishida
Junichi Yamamoto
Takumi Ito
Muneyoshi Futami
Masaki Ri
Hiroshi Yasui
Tamami Denda
Yukihisa Tanaka
Yasunori Ota
Masanori Nojima
Yasuhiko Kamikubo
Noriko Gotoh
Shinsuke Iida
Hiroshi Handa
Arinobu Tojo
机构：
[1] The Institute of Medical Science,Division of Molecular Therapy, Advanced Clinical Research Center
[2] The University of Tokyo,Department of Hematology/Oncology, Research Hospital
[3] The Institute of Medical Science,Division of Cancer Cell Biology
[4] The University of Tokyo,School of Life Science and Technology
[5] Cancer Research Institute of Kanazawa University,Department of Chemical Biology
[6] Department of Hematology,Department of Hematology & Oncology
[7] Japanese Red Cross Medical Center,Project Division of Fundamental Study on Cutting Edge of Genome Medicine
[8] Tokyo Institute of Technology,Department of Pathology, Research Hospital
[9] Tokyo Medical University,undefined
[10] Nagoya City University Graduate School of Medical Sciences,undefined
[11] The Institute of Medical Science,undefined
[12] The University of Tokyo,undefined
[13] The Institute of Medical Science,undefined
[14] The University of Tokyo,undefined
[15] Center for Translational Research/Division of Advanced Medicine Promotion The Institute of Medical Science,undefined
[16] The University of Tokyo,undefined
[17] Laboratory of Oncology and Strategic Innovation,undefined
[18] Laboratory Science,undefined
[19] Graduate School of Medicine Kyoto University,undefined
来源：
Journal of Experimental & Clinical Cancer Research | / 40卷
关键词：
Multiple myeloma; Cereblon; Drug-resistance; HDAC inhibitor; Akt inhibitor; Dual HDAC and PI3K inhibitor; Natural killer group 2D ligands; C-Myc; Monoclonal antibody; Antibody-dependent cellular cytotoxicity;
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