Studies on pyrazine derivatives. 38*. Synthesis, reactions, and tuberculostatic activity of pyrazinyl-substituted derivatives of hydrazinocarbodithioic acid

被引：4
|
作者：
Foks H. [1 ]
Trapkowska I. [1 ]
Janowiec M. [2 ]
Zwolska Z. [2 ]
Augustynowicz-Kopec E. [2 ]
机构：
[1] Department of Organic Chemistry, Medical University of Gdansk
[2] Department of Microbiology, Institute of Tuberculosis and Pulmonary Diseases
来源：
Chemistry of Heterocyclic Compounds | 2004年 / 40卷 / 9期
关键词：
1,2,4-triazoles; 1,3,4-thiadiazole-2-thiol; 6-chloro-2-cyanopyrazine; Amidrazones; Carbon disulfide; Imino esters; Mono- and diesters of hydrazinocarbodithioic acids; Tuberculostatics;
D O I：
10.1023/B:COHC.0000048293.68655.d5
中图分类号：
学科分类号：
摘要：
The synthesis of N'-[amino(6-chloro- and 6-cycloaminopyrazin-2-yl) methylene]carbodithioic acid mono- and diesters and their reactions are described. Cyclization of monoesters with secondary amines in acidic media gave the 1,3,4-thiadiazole derivatives, while the cyclization of diesters with amines yielded 1,2,4-triazoles with the amine substituent in position 3. The in vitro tuberculostatic activity of the prepared compounds was tested. ©2004 Springer Science+Business Media, Inc.
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页码：1185 / 1193
页数：8
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