Guiding dengue vaccine development using knowledge gained from the success of the yellow fever vaccine

被引：0
|
作者：
Huabin Liang
Min Lee
Xia Jin
机构：
[1] Viral Disease and Vaccine Translational Research Unit,
[2] and Vaccine Centre,undefined
[3] Institut Pasteur of Shanghai,undefined
[4] Chinese Academy of Sciences,undefined
来源：
Cellular & Molecular Immunology | 2016年 / 13卷
关键词：
dengue virus; protective immunity; vaccine; yellow fever;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Flaviviruses comprise approximately 70 closely related RNA viruses. These include several mosquito-borne pathogens, such as yellow fever virus (YFV), dengue virus (DENV), and Japanese encephalitis virus (JEV), which can cause significant human diseases and thus are of great medical importance. Vaccines against both YFV and JEV have been used successfully in humans for decades; however, the development of a DENV vaccine has encountered considerable obstacles. Here, we review the protective immune responses elicited by the vaccine against YFV to provide some insights into the development of a protective DENV vaccine.
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页码：36 / 46
页数：10
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