Optimization of the composition and wet granulation technology of drotaverine hydrochloride tablets

被引：0
|
作者：
Gavrilov A.S. [1 ]
Gusel'nikova E.V. [1 ]
Petrov A.Yu. [1 ]
机构：
[1] Ural Institute of Medicinal Preparation Technology, Yekaterinburg
来源：
Pharmaceutical Chemistry Journal | 2005年 / 39卷 / 5期
关键词：
Organic Chemistry; Relative Humidity; Hydrochloride; Solution Stability; Drug Solution;
D O I：
10.1007/s11094-005-0131-y
中图分类号：
学科分类号：
摘要：
The process of drotaverine hydrochloride decomposition is modeled using data on the drug solution stability and the variation of RGB color coordinates of drotaverine hydrochloride tablets. The introduction of an acid into the drug composition ensures obtaining high-quality tablets of yellow-green color. The pressing of granules with dimensions below 0.6 mm and a relative humidity above 1.8% provides for a uniform coloration of tablets. © 2005 Springer Science+Business Media, Inc.
引用
收藏
页码：274 / 277
页数：3
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