Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells

被引：0
|
作者：
Susobhan Sarkar
Axinia Döring
Franz J Zemp
Claudia Silva
Xueqing Lun
Xiuling Wang
John Kelly
Walter Hader
Mark Hamilton
Philippe Mercier
Jeff F Dunn
Dave Kinniburgh
Nico van Rooijen
Stephen Robbins
Peter Forsyth
Gregory Cairncross
Samuel Weiss
V Wee Yong
机构：
[1] University of Calgary,Department of Clinical Neurosciences
[2] Hotchkiss Brain Institute,Department of Molecular Cell Biology
[3] University of Calgary,undefined
[4] The Southern Alberta Cancer Research Institute,undefined
[5] University of Calgary,undefined
[6] Centre for Toxicology,undefined
[7] University of Calgary,undefined
[8] Vrije Universiteit,undefined
来源：
Nature Neuroscience | 2014年 / 17卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Growth of malignant glioma involves a rare population of stem-like cells in the brain called brain tumor-initiating cells (BTICs). This study shows that immune cells in the brain can attenuate tumorigenic capacity of cancer patient-derived BTICs. The authors also identify a drug amphotericin B as an activator of microglia and macrophages that can enhance the microglial activation and mitigate BTIC proliferation in culture. This drug also improved the lifespan of a mouse model of malignant glioma in vivo.
引用
收藏
页码：46 / 55
页数：9
相关论文
共 50 条
  • [1] Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells
    Sarkar, Susobhan
    Doering, Axinia
    Zemp, Franz J.
    Silva, Claudia
    Lun, Xueqing
    Wang, Xiuling
    Kelly, John
    Hader, Walter
    Hamilton, Mark
    Mercier, Philippe
    Dunn, Jeff F.
    Kinniburgh, Dave
    van Rooijen, Nico
    Robbins, Stephen
    Forsyth, Peter
    Cairncross, Gregory
    Weiss, Samuel
    Yong, V. Wee
    ANNALS OF NEUROSCIENCES, 2013, 20 (04) : 154 - 154
  • [2] Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells
    Sarkar, Susobhan
    Doering, Axinia
    Zemp, Franz J.
    Silva, Claudia
    Lun, Xueqing
    Wang, Xiuling
    Kelly, John
    Hader, Walter
    Hamilton, Mark
    Mercier, Philippe
    Dunn, Jeff F.
    Kinniburgh, Dave
    van Rooijen, Nico
    Robbins, Stephen
    Forsyth, Peter
    Cairncross, Gregory
    Weiss, Samuel
    Yong, V. Wee
    NATURE NEUROSCIENCE, 2014, 17 (01) : 46 - 55
  • [3] The battle for the brain Brain tumor-initiating cells vs. microglia/macrophages
    Sarkar, Susobhan
    Yong, V. Wee
    ONCOIMMUNOLOGY, 2014, 3 (02)
  • [4] STIMULATION OF MICROGLIA AND MACROPHAGES AND GROWTH ATTENUATION OF BRAIN TUMOR-INITIATING CELLS WITH TUMOR NECROSIS FACTOR-ALPHA
    Poon, Candice C.
    Sarkar, Susobhan
    Blough, Michael
    Cairncross, J. Gregory
    Yong, V. Wee
    Kelly, John
    NEURO-ONCOLOGY, 2016, 18 : 189 - 189
  • [5] Aptamer Identification of Brain Tumor-Initiating Cells
    Kim, Youngmi
    Wu, Qiulian
    Hamerlik, Petra
    Hitomi, Masahiro
    Sloan, Andrew E.
    Barnett, Gene H.
    Weil, Robert J.
    Leahy, Patrick
    Hjelmeland, Anita B.
    Rich, Jeremy N.
    CANCER RESEARCH, 2013, 73 (15) : 4923 - 4936
  • [6] BRAIN TUMOR-INITIATING CELLS AND CELLS OF ORIGIN IN GLIOBLASTOMA
    Agnihotri, Sameer
    Munoz, Diana
    Zadeh, Gelareh
    Guha, Abhijit
    TRANSLATIONAL NEUROSCIENCE, 2011, 2 (04) : 331 - 338
  • [7] Microglia induces Gas1 expression in human brain tumor-initiating cells to reduce tumorigenecity
    Susobhan Sarkar
    Candice C. Poon
    Reza Mirzaei
    Khalil S. Rawji
    Walter Hader
    Pinaki Bose
    John Kelly
    Jeffrey F. Dunn
    V. Wee Yong
    Scientific Reports, 8
  • [8] Microglia induces Gas1 expression in human brain tumor-initiating cells to reduce tumorigenecity
    Sarkar, Susobhan
    Poon, Candice C.
    Mirzaei, Reza
    Rawji, Khalil S.
    Hader, Walter
    Bose, Pinaki
    Kelly, John
    Dunn, Jeffrey F.
    Yong, V. Wee
    SCIENTIFIC REPORTS, 2018, 8
  • [9] BIOLOGIC AND THERAPEUTIC ROLE OF TELOMERE MAINTENANCE IN TUMOR-INITIATING CELLS
    Castello-Branco, Pedro
    Zhang, Cindy
    Hansford, Loen
    Lipman, Tatiana
    Clarke, Ian D.
    Harley, Calvin
    Tressler, Robert
    Go, Ning
    Bassett, Katia
    Kaplan, David
    Dirks, Peter B.
    Tabori, Uri
    NEURO-ONCOLOGY, 2009, 11 (05) : 683 - 683
  • [10] Tumor-Initiating Cells and Tumor Vascularization
    Zhang, Li-Zhi
    Zhang, Chang-Qing
    Yan, Zhen-Yu
    Yang, Qing-Cheng
    Jiang, Yao
    Zeng, Bing-Fang
    PEDIATRIC BLOOD & CANCER, 2011, 56 (03) : 335 - 340
12345