Impact of body mass index on neuronal fiber bundle lengths among healthy older adults
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作者:
Jacob D. Bolzenius
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机构:University of Missouri-Saint Louis,Computer Science Department
Jacob D. Bolzenius
David H. Laidlaw
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机构:University of Missouri-Saint Louis,Computer Science Department
David H. Laidlaw
Ryan P. Cabeen
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机构:University of Missouri-Saint Louis,Computer Science Department
Ryan P. Cabeen
Thomas E. Conturo
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机构:University of Missouri-Saint Louis,Computer Science Department
Thomas E. Conturo
Amanda R. McMichael
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机构:University of Missouri-Saint Louis,Computer Science Department
Amanda R. McMichael
Elizabeth M. Lane
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机构:University of Missouri-Saint Louis,Computer Science Department
Elizabeth M. Lane
Jodi M. Heaps
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机构:University of Missouri-Saint Louis,Computer Science Department
Jodi M. Heaps
Lauren E. Salminen
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机构:University of Missouri-Saint Louis,Computer Science Department
Lauren E. Salminen
Laurie M. Baker
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机构:University of Missouri-Saint Louis,Computer Science Department
Laurie M. Baker
John Gunstad
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机构:University of Missouri-Saint Louis,Computer Science Department
John Gunstad
Robert H. Paul
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机构:University of Missouri-Saint Louis,Computer Science Department
Robert H. Paul
机构:
[1] University of Missouri-Saint Louis,Computer Science Department
[2] One University Boulevard,Mallinckrodt Institute of Radiology
[3] Brown University,Department of Psychology
[4] Washington University School of Medicine,undefined
[5] Vanderbilt University Medical Center,undefined
[6] Kent State University,undefined
来源:
Brain Imaging and Behavior
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2013年
/
7卷
关键词:
Tractography;
BMI;
DTI;
White matter;
Fiber bundle length;
Aging;
D O I:
暂无
中图分类号:
学科分类号:
摘要:
Increased body mass index (BMI) has been linked to various detrimental health outcomes, including cognitive dysfunction. Recent work investigating associations between obesity and the brain has revealed decreased white matter microstructural integrity in individuals with elevated BMI, independent of age or comorbid health conditions. However, the relationship between high BMI and white matter fiber bundle length (FBL), which represents a novel metric of microstructural brain integrity, remains unknown. The present study utilized quantitative tractography based on diffusion tensor imaging (DTI) to investigate the relationship between BMI and FBL in 72 otherwise healthy older adults (24 males, 48 females). All participants were between 51 and 85 years of age (M = 63.26, SD = 8.76). Results revealed that elevated BMI was associated with shorter FBL in the temporal lobe, independent of age (p < .01). In addition, increased age was associated with shorter frontal, temporal, and whole brain FBL (all p values < .01). These findings indicate that, while increased age is an important factor associated with reduced FBL, high BMI is uniquely associated with reduced FBL in the temporal lobe. These data offer evidence for additive adverse effects of high BMI on the brain, especially in areas already vulnerable to aging processes and age-related neurodegenerative diseases. Further research is necessary to determine the physiological mechanisms associated with the shortening of FBL in individuals with high BMI.
机构:
Penn State Univ, Dept Nutr Sci, University Pk, PA 16802 USAPenn State Univ, Dept Nutr Sci, University Pk, PA 16802 USA
Cheng, Feon W.
Gao, Xiang
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机构:
Penn State Univ, Dept Nutr Sci, University Pk, PA 16802 USAPenn State Univ, Dept Nutr Sci, University Pk, PA 16802 USA
Gao, Xiang
Mitchell, Diane C.
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机构:
Penn State Univ, Dept Nutr Sci, University Pk, PA 16802 USAPenn State Univ, Dept Nutr Sci, University Pk, PA 16802 USA
Mitchell, Diane C.
Wood, Craig
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h-index: 0
机构:
Geisinger Hlth Syst, Dept Internal Med, Danville, PA USA
Geisinger Hlth Syst, Obes Inst, Danville, PA USAPenn State Univ, Dept Nutr Sci, University Pk, PA 16802 USA
Wood, Craig
Still, Christopher D.
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h-index: 0
机构:
Geisinger Hlth Syst, Dept Internal Med, Danville, PA USA
Geisinger Hlth Syst, Obes Inst, Danville, PA USAPenn State Univ, Dept Nutr Sci, University Pk, PA 16802 USA
Still, Christopher D.
Rolston, David
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机构:
Geisinger Hlth Syst, Dept Internal Med, Danville, PA USA
Geisinger Hlth Syst, Obes Inst, Danville, PA USAPenn State Univ, Dept Nutr Sci, University Pk, PA 16802 USA
Rolston, David
Jensen, Gordon L.
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机构:
Penn State Univ, Dept Nutr Sci, University Pk, PA 16802 USA
Univ Vermont, Coll Med, Deans Off, Burlington, VT USA
Univ Vermont, Coll Med, Dept Med, Burlington, VT 05405 USAPenn State Univ, Dept Nutr Sci, University Pk, PA 16802 USA