Successful third-line chemotherapy for an adult with recurrent medulloblastoma

Medulloblastoma is a rare tumor in adults. There is no standard treatment, and extrapolation of treatment results from the pediatric population is flawed by differences in behavior of the tumor and in tolerance of treatment at different ages. In this case report, a patient with medulloblastoma and leptomeningeal metastases after standard chemoradiotherapy had rapid progressive disease after second-line temozolomide. However, partial response was achieved with third-line etoposide and carboplatin. Treatment choice should be based on toxicity management and the patient’s history to obtain higher efficacy, as in our case.