Synthesis and anti-inflammatory evaluation of new pyrazoles bearing biodynamic thiazole and thiazolidinone scaffolds

New trisubstituted pyrazoles bearing thiazolyl and thiazolidinonyl moieties have been successfully and conveniently synthesized in three steps using 5-acetyl thiazoles (1a–b) as starting materials. The route includes the synthesis of new intermediates, 4-formyl 5-thiazolyl pyrazoles (4a–b). The formyl pyrazoles on one pot cyclocondensation with anilines and thioglycolic acid have been found to yield the titled compounds (7a–j). The new pyrazoles have been screened to evaluate in vivo anti-inflammatory activity and compounds 7c, 7d, 7f, 7g, 7h, and 7i have better anti-inflammatory activity than reference drug Celecoxib. The synthetic details and results of anti-inflammatory activity are discussed.