Fluorescence analysis of the action of soluble derivatives of fullerene C60 on amyloid fibrils of the brain peptide Aβ(1-42)

被引：4
|
作者：
Bobylev A.G. [1 ]
Marsagishvili L.G. [1 ]
Podlubnaya Z.A. [1 ,2 ]
机构：
[1] Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino
[2] Pushchino State University, Pushchino
来源：
Biophysics | 2010年 / 55卷 / 5期
基金：
俄罗斯基础研究基金会;
关键词：
Aβ(1-42)-peptide; Alzheimer's disease; fullerenes; neurodegenerative diseases; thioflavin T;
D O I：
10.1134/S0006350910050027
中图分类号：
学科分类号：
摘要：
It has been shown by fluorescence analysis in vitro that the water-soluble sodium salt of the polycarboxylic derivative of fullerene C60, fullerenol, and complexes of fullerene C60 with polyvinylpyrrolidone (mol. wt. 25000 and 10000) destroy amyloid fibrils of the brain peptide Aβ(1-42) and prevent their formation. The results of fluorescence analysis confirmed the data obtained earlier by high-resolution electron microscopy. Fluorescence analysis and electron microscopy are complementary methods for the selection of effective antiamyloid drugs. © 2010 Pleiades Publishing, Ltd.
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收藏
页码：699 / 702
页数：3
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