Circular RNA GRB10 as a competitive endogenous RNA regulating nucleus pulposus cells death in degenerative intervertebral disk

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作者：
Wei Guo
Bin Zhang
Kun Mu
Shi-Qing Feng
Zhan-Yin Dong
Guang-Zhi Ning
Hao-Ran Li
Shen Liu
Ling Zhao
Yan Li
Bing-Bing Yu
Hui-Quan Duan
Chao Sun
Yong-Jin Li
机构：
[1] Hebei Province Cangzhou Hospital of Integrated Traditional and Western Medicine (Cangzhou No.2 Hospital),Department of Orthopaedics
[2] Tianjin Medical University General Hospital,Department of Orthopaedics
[3] Hebei Province Cangzhou Hospital of Integrated Traditional and Western Medicine (Cangzhou No.2 Hospital),Department of Breast Surgery
来源：
Cell Death & Disease | / 9卷
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摘要：
Intervertebral disc degeneration (IDD) is an important factor leading to low back pain, but the underlying mechanisms remain poorly understood. Compared with normal nucleus pulposus (NP) tissues, the expression of circ-GRB10 was downregulated in IDD. Furthermore, overexpression of circ-GRB10 inhibited NP cell apoptosis. circ-GRB10 could sequester miR-328-5p, which could potentially lead to the upregulation of target genes related to cell proliferation via the ErbB pathway. In conclusion, the present study revealed that circ-GRB10/miR-328-5p/ERBB2 signaling pathway is involved in IDD development, suggesting that circ-GRB10 might be a novel therapeutic target for IDD.
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