Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase

被引：0

作者：

Virginia Guarani

Gianluca Deflorian

Claudio A. Franco

Marcus Krüger

Li-Kun Phng

Katie Bentley

Louise Toussaint

Franck Dequiedt

Raul Mostoslavsky

Mirko H. H. Schmidt

Barbara Zimmermann

Ralf P. Brandes

Marina Mione

Christoph H. Westphal

Thomas Braun

Andreas M. Zeiher

Holger Gerhardt

Stefanie Dimmeler

Michael Potente

机构：

[1] Institute for Cardiovascular Regeneration,Department of Cardiac Development and Remodeling

[2] Centre of Molecular Medicine,Department of Cardiology

[3] Goethe University,undefined

[4] IFOM,undefined

[5] the FIRC Institute of Molecular Oncology,undefined

[6] IFOM-IEO Campus,undefined

[7] Vascular Biology Laboratory,undefined

[8] London Research Institute – Cancer Research UK,undefined

[9] Max Planck Institute for Heart and Lung Research,undefined

[10] Laboratory of Protein Signaling and Interactions,undefined

[11] GxABT,undefined

[12] B-5030 Gembloux and Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R),undefined

[13] University of Liege,undefined

[14] Massachusetts General Hospital Cancer Center,undefined

[15] Harvard Medical School,undefined

[16] Molecular Signal Transduction,undefined

[17] Institute of Neurology (Edinger Institute),undefined

[18] Goethe University,undefined

[19] Vascular Research Centre,undefined

[20] Institute for Cardiovascular Physiology,undefined

[21] Goethe University,undefined

[22] Sirtris,undefined

[23] a GSK Company,undefined

[24] Internal Medicine III,undefined

[25] Goethe University,undefined

[26] Consultant Group Leader,undefined

[27] Vascular Patterning Laboratory,undefined

[28] Vesalius Research Center,undefined

[29] VIB,undefined

[30] Campus Gasthuisberg,undefined

[31] Present address: Cell Biology and Biophysics,undefined

[32] European Molecular Biology Laboratory,undefined

[33] D-69117 Heidelberg,undefined

[34] Germany.,undefined

来源：

Nature | 2011年 / 473卷

关键词：

D O I：

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中图分类号：

学科分类号：

摘要：

Notch signalling coordinates angiogenesis by controlling the specification of endothelial cells into tip cells that lead the way in growing blood vessels and the stalk cells that follow. Michael Potente and colleagues have identified a previously unknown component in Notch signalling regulation in endothelial cells that may provide a mechanism for fine-tuning angiogenesis in response to metabolic requirements and angiogenic stress. They show that the metabolism- and redox-sensing deacetylase SIRT1 deacetylates the Notch1 intracellular domain directly, thereby controlling its stability and turnover and negatively modulating Notch signalling. Inactivation of SIRT1 impairs angiogenesis in zebrafish and mice.

引用

页码：234 / 238

页数：4

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