Vemurafenib provides a rapid and robust clinical response in pediatric Langerhans cell histiocytosis with the BRAF V600E mutation but does not eliminate low-level minimal residual disease per ddPCR using cell-free circulating DNA

被引：0
|
作者：
Dmitry Evseev
Irina Kalinina
Elena Raykina
Daria Osipova
Zalina Abashidze
Anna Ignatova
Anna Mitrofanova
Alexey Maschan
Galina Novichkova
Michael Maschan
机构：
[1] Dmitry Rogachev National Medical Research Center of Pediatric Hematology,
[2] Oncology and Immunology,undefined
来源：
International Journal of Hematology | 2021年 / 114卷
关键词：
Histiocytosis; Langerhans cell histiocytosis; Molecular biology;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：725 / 734
页数：9
相关论文
共 15 条
  • [1] Vemurafenib provides a rapid and robust clinical response in pediatric Langerhans cell histiocytosis with the BRAF V600E mutation but does not eliminate low-level minimal residual disease per ddPCR using cell-free circulating DNA
    Evseev, Dmitry
    Kalinina, Irina
    Raykina, Elena
    Osipova, Daria
    Abashidze, Zalina
    Ignatova, Anna
    Mitrofanova, Anna
    Maschan, Alexey
    Novichkova, Galina
    Maschan, Michael
    INTERNATIONAL JOURNAL OF HEMATOLOGY, 2021, 114 (06) : 725 - 734
  • [2] BRAF V600E Mutation in Pediatric Langerhans Cell Histiocytosis and its Clinical Significance
    Wang, Dong
    Zhang, Rui
    Lian, Hong-yun
    Ma, Hong-hao
    Gao, Chao
    Wang, Tian-you
    Zhang, Li
    PEDIATRIC BLOOD & CANCER, 2016, 63 : S35 - S35
  • [3] Circulating cell-free BRAF V600E during chemotherapy is associated with prognosis of children with Langerhans cell histiocytosis
    Cui, Lei
    Zhang, Li
    Ma, Hong-Hao
    Wang, Chan-Juan
    Wang, Dong
    Lian, Hong-Yun
    Li, Wei-Jing
    Zhang, Qing
    Li, Na
    Wang, Tian-You
    Li, Zhi-Gang
    Zhang, Rui
    HAEMATOLOGICA, 2020, 105 (09) : E444 - E447
  • [4] Major response to vemurafenib in patient with severe cutaneous Langerhans cell histiocytosis harboring BRAF V600E mutation
    Charles, Julie
    Beani, Jean-Claude
    Fiandrino, Giacomo
    Busser, Benoit
    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2014, 71 (03) : E97 - E99
  • [5] BRAF V600E Mutation: A Significant Biomarker for Prediction of Disease Relapse in Pediatric Langerhans Cell Histiocytosis
    Ozer, Erdener
    Sevinc, Akin
    Ince, Dilek
    Yuzuguldu, Resmiye
    Olgun, Nur
    PEDIATRIC AND DEVELOPMENTAL PATHOLOGY, 2019, 22 (05) : 449 - 455
  • [6] BRAF-V600E Mutation on Circulating Cell-Free DNA Is a Promising Biomarker of High-Risk Adult Langerhans Cell Histiocytosis
    Kobayashi, Masayuki
    Ohno, Nobuhiro
    Fukuyama, Tomofusa
    Kawamata, Toyotaka
    Uchimaru, Kaoru
    Tojo, Arinobu
    BLOOD, 2014, 124 (21)
  • [7] The BRAF-V600E mutation in circulating cell-free DNA is a promising biomarker of high-risk adult Langerhans cell histiocytosis
    Kobayashi, Masayuki
    Tojo, Arinobu
    BLOOD, 2014, 124 (16) : 2610 - 2611
  • [8] Dramatic efficacy of vemurafenib in both multisystemic and refractory Erdheim-Chester disease and Langerhans cell histiocytosis harboring the BRAF V600E mutation
    Haroche, Julien
    Cohen-Aubart, Fleur
    Emile, Jean-Francois
    Arnaud, Laurent
    Maksud, Philippe
    Charlotte, Frederic
    Cluzel, Philippe
    Drier, Aurelie
    Hervier, Baptiste
    Benameur, Neila
    Besnard, Sophie
    Donadieu, Jean
    Amoura, Zahir
    BLOOD, 2013, 121 (09) : 1495 - 1500
  • [9] Clinical Implications of Cell-Free DNA in Managing BRAF V600E Mutation-Positive Colorectal Cancer
    Iwai, Takuma
    Yamada, Takeshi
    Uehara, Kay
    Shinji, Seiichi
    Matsuda, Akihisa
    Yokoyama, Yasuyuki
    Takahashi, Goro
    Miyasaka, Toshimitsu
    Yoshida, Hiroshi
    GENES, 2025, 16 (03)
  • [10] BRAF V600E mutation correlates with suppressive tumor immune microenvironment and reduced disease-free survival in Langerhans cell histiocytosis
    Zeng, Kaixuan
    Wang, Zhe
    Ohshima, Koichi
    Liu, Yixiong
    Zhang, Weichen
    Wang, Lu
    Fan, Linni
    Li, Mingyang
    Li, Xia
    Wang, Yingmei
    Yu, Zhou
    Yan, Qingguo
    Guo, Shuangping
    Wei, Jie
    Guo, Ying
    ONCOIMMUNOLOGY, 2016, 5 (07):
12