Attenuating effect of daidzein on polychlorinated biphenyls-induced oxidative toxicity in mouse testicular cells

被引：0
|
作者：
Da-lei Zhang
Yu-ling Mi
Kai-ming Wang
Wei-dong Zeng
Cai-qiao Zhang
机构：
[1] Zhejiang University,College of Animal Sciences
[2] Nanchang University,Department of Physiology, College of Medicine
来源：
Journal of Zhejiang University SCIENCE B | 2008年 / 9卷
关键词：
Daidzein (DAI); Polychlorinated biphenyl (PCB); Oxidative damage; Germ cell; Q95;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The attenuating effect of daidzein (DAI) on oxidative toxicity induced by Aroelor 1254 (A1254) was investigated in mouse testicular cells. Cells were exposed to A1254 alone or with DAI. The oxidative damage was estimated by measuring malondialdehyde (MDA) formation, superoxide dismutase (SOD) activity and glutathione (GSH) content. Results show that A1254 induced a decrease of germ cell number, an elevation in thiobarbituric acid reactive substances (TBARS) but a decrease in SOD activity and GSH content. However, simultaneous supplementation with DAI decreased TBARS level and increased SOD activity and GSH content. Consequently, dietary DAI may restore the intracellular antioxidant system to attenuate the oxidative toxicity of A1254 in testicular cells.
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页码：567 / 571
页数：4
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