The Role of Steroid Receptor Coactivators in Hormone Dependent Cancers and Their Potential as Therapeutic Targets

被引：0
|
作者：
Lei Wang
David M. Lonard
Bert W. O’Malley
机构：
[1] Baylor College of Medicine,Department of Molecular and Cellular Biology
来源：
Hormones and Cancer | 2016年 / 7卷
关键词：
Androgen Receptor; Focal Adhesion Kinase; Breast Cancer Cell Proliferation; Steroid Receptor Coactivator; Steroid Hormone Signaling;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Steroid receptor coactivator (SRC) family members (SRC-1, SRC-2, SRC-3) interact with nuclear receptors (NRs) and many transcription factors to enhance target gene transcription. Deregulation of SRCs is widely implicated in NR mediated diseases, especially hormone dependent cancers. By integrating steroid hormone signaling and growth factor pathways, SRC proteins exert multiple modes of oncogenic regulation in cancers and represent emerging targets for cancer therapeutics. Recent work has identified SRC-targeting agents that show promise in blocking tumor growth in vitro and in vivo, and have the potential to function as powerful and broadly encompassing treatments for different cancers.
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页码：229 / 235
页数：6
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