RNA interference in embryonic stem cells and the prospects for future therapies

被引：0
|
作者：
A Heidersbach
A Gaspar-Maia
M T McManus
M Ramalho-Santos
机构：
[1] Diabetes Center,
[2] University of California,undefined
[3] Program in Developmental and Stem Cell Biology,undefined
[4] University of California,undefined
来源：
Gene Therapy | 2006年 / 13卷
关键词：
miRNA; ES cells; RNAi; siRNA; differentiation; cell-replacement therapy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In 1998, two distinct and exciting scientific fields emerged which have profoundly shaped the current direction of biomedical research. The discovery of RNA interference (RNAi) and the derivation of human embryonic stem (ES) cells have yielded exciting new possibilities for researchers and clinicians alike. While fundamentally different, aspects from these two fields may be combined to yield extraordinary scientific and medical benefits. Here, we review the prospects of combining RNAi and ES cell manipulation for both basic research and future therapies, as well as current limitations and obstacles that need to be overcome.
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页码：478 / 486
页数：8
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