The effect of chlorpromazine on intracellular Ca2+ concentration in macrophages

被引：0
|
作者：
Z. I. Krutetskaya
L. S. Milenina
A. A. Naumova
S. N. Butov
V. G. Antonov
A. D. Nozdrachev
机构：
[1] St. Petersburg State University,
来源：
Doklady Biochemistry and Biophysics | 2017年 / 474卷
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摘要：
Using Fura-2AM microfluorimetry, it was shown for the first time that neuroleptic chlorpromazine causes intracellular Ca2+ concentration increase in macrophages due to Ca2+ mobilization from intracellular Ca2+ stores and subsequent Ca2+ entry from the external medium. Chlorpromazine-induced Ca2+ entry is inhibited by La3+ and 2-aminoethoxydiphenyl borate and is associated with Ca2+ store depletion.
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页码：162 / 164
页数：2
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