Improving cytopenia with splenic artery embolization in a patient with paroxysmal nocturnal hemoglobinuria on eculizumab

被引：0
|
作者：
Suresh K. Krishnan
Anita Hill
Peter Hillmen
Louise M. Arnold
Gemma L. Brooksbank
Alex Wood
Andrew Scarsbrook
Mervyn H. Davies
Richard J. Kelly
机构：
[1] St-James University Hospital,Department of Hematology/Oncology
[2] St-James University Hospital,Department of Hepatology
[3] St-James University Hospital,Department of Radiology
来源：
International Journal of Hematology | 2013年 / 98卷
关键词：
Paroxysmal nocturnal hemoglobinuria; Eculizumab; Splenic artery embolization; Cytopenia;
D O I：
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摘要：
Paroxysmal nocturnal hemoglobinuria is a rare acquired stem cell disorder characterized by intravascular hemolysis, aplasia and an increased risk of thrombosis. We describe a patient under treatment with the anti-complement antibody eculizumab who developed pancytopenia, requiring blood transfusions, due to massive splenomegaly. The patient underwent two separate splenic embolizations, which reduced the size of the spleen and improved his blood count to the point that blood transfusions were no longer necessary. Splenic embolization was chosen over splenectomy due to the potential postoperative complications of splenectomy, especially that of thrombosis.
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页码：716 / 718
页数：2
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