Dynamics of chromosomal aberrations in male mice of various strains during aging

被引：0
|
作者：
Rozenfel'd S.V. [1 ]
Togo E.F. [1 ]
Mikheev V.S. [1 ]
Popovich I.G. [2 ]
Zabezhinskii M.A. [2 ]
Anisimov V.N. [2 ]
机构：
[1] Department of Biology and Genetics, I. P. Pavlov St. Petersburg State Medical University, St. Petersburg
[2] Department of Carcinogenesis and Oncogerontology, N. N. Petrov Institute of Oncology, St. Petersburg
来源：
Bulletin of Experimental Biology and Medicine | 2001年 / 131卷 / 5期
关键词：
Aging; Chromosomal aberrations; Interstrain differences; Mice;
D O I：
10.1023/A:1017940418751
中图分类号：
学科分类号：
摘要：
We studied the incidence of chromosome aberrations in bone marrow cells and primary spermatocytes in various mouse strains. Experiments were performed on SAMP mice (accelerated aging), control SAMR mice, and long-living CBA and SHR mice. Experiments revealed a positive correlation between the age and the incidence of mutations in their somatic cells and gametes.
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页码：482 / 483
页数：1
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