Three new nor-dammarane triterpenoids from Dysoxylum hainanense with particular cytotoxicity against glioma cell line

被引：0
|
作者：
Peng Cao
Guobiao Liang
Xu Gao
Xiaogang Wang
Zhiqing Li
机构：
[1] Shenyang Northern Hospital,Department of Neurosurgery
来源：
Archives of Pharmacal Research | 2013年 / 36卷
关键词：
Meliaceae; Nor-dammarane triterpenoids; Cytotoxicity;
D O I：
暂无
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学科分类号：
摘要：
Three new nor-dammarane triterpenoids, 12β-O-acetyl-15α-hydoxy-3-oxo-17-en-20,21,22-23,24,25,26,27-octanordammanran (1), 12β,28-O-diacetyl-15α-hydoxy-3-oxo-17-en-20,21,22-23,24,25,26,27-octanordammanran (2), 12β-hydoxy-3,15-dioxo-20,21,22-23,24,25,26,27-octanordammanran (3), together with one known compound, 12β-O-acetyl-15α,28-dihydoxy-3-oxo-17-en-20,21,22-23,24,25,26,27-octanordammanran (4), were isolated from the 95 % EtOH extract of Dysoxylum hainanense. The structures of the new compounds were elucidated by spectral methods. All the triterpenoids were in vitro evaluated for their cytotoxic activities against four tumor cell lines (BGC-823, U251, HepG2 and SGC-7901). All the three nor-dammarane triterpenoids exhibited particular significant cytotoxic activities against glioma cell line.
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页码：322 / 326
页数：4
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