Signaling pathways to neuronal damage ad apoptosis in human immunodeficiency virus type 1-associated dementia: Chemokine receptors, excitotoxicity, and beyond

被引：0
|
作者：
Kaul M. [1 ]
Lipton S.A. [1 ]
机构：
[1] The Burnham Institute, Ctr. for Neuroscience/Aging Research, La Jolla, CA 92037
来源：
Journal of NeuroVirology | 2004年 / 10卷 / Suppl 1期
关键词：
AIDS; Chemokine receptors; HIV-1 envelope glycoprotein; Matrix metalloproteinase; Nitrosylation; NMDA receptor;
D O I：
10.1080/753312759
中图分类号：
学科分类号：
摘要：
Dementia can occur as a debilitating consequence of human immunodeficiency virus-1 (HIV-1) infection. The neuropathology incited by HIV infection involves activation of chemokine receptors, inflammatory factors, and N-methyl-D-aspartate (NMDA) receptor-mediated excitotoxicity, all of which can activate several downstream mechanisms. This article discusses recently identified pathways to neuronal damage triggered by HIV-1 and efforts aimed at development of applicable therapeutic intervention. © 2004 Journal of NeuroVirology.
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页码：97 / 101
页数：4
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