[6]-Gingerol prevents gamma radiation-induced cell damage in HepG2 cells

被引：0
|
作者：
Dong-Min Chung
S. M. Nasir Uddin
Jin-Hong Kim
Jin Kyu Kim
机构：
[1] Advanced Radiation Technology Institute,
[2] Korea Atomic Energy Research Institute,undefined
[3] Korea University of Science and Technology (UST),undefined
来源：
Journal of Radioanalytical and Nuclear Chemistry | 2015年 / 305卷
关键词：
[6]-Gingerol; Radiation protection; HepG2; Cytotoxicity; Oxidative stress; Apoptosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The mechanism by which [6]-gingerol exerts radioprotective effects remains unknown. The aim of this study was to examine the radioprotective effects of [6]-gingerol in HepG2 cells. Our results showed that 50 % cell death and GSH depletion were caused by 5 Gy gamma irradiation. [6]-Gingerol pretreatment partially prevented those effects. Moreover, the elevated expression of proapoptotic protein p53 and Bax following gamma irradiation was decreased by [6]-gingerol pretreatment whereas the declined expression of antiapoptotic protein Bcl-2 was increased. It was concluded that [6]-gingerol has a protective effect against radiation-induced cell damage related to oxidative stress and apoptosis.
引用
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页码：323 / 328
页数：5
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